His first big hit was Ang Pagdadalaga ni Maximo Oliveros (English: The Blossoming of Maximo Oliveros) in 2005 where he played a 12-year-old gay who comes from a criminal family and falls in love with a handsome policeman. He won 2 awards for the movie. Another TV series he worked on was away back in 2007, entitled, "Sana Maulit Muli" (English: I Wish It Could Happen Again). He played the role of Romeo, a gay friend of the leading actress in the story, which is Kim Chiu, named Jasmine in the story. Nathan is currently working on a morning TV series entitled Be Careful with My Heart as Emman, the gay friend of Maya (played by Jodi Santamaria). The series is airing in the Philippines on the ABS-CBN network. Despite playing his third gay role, Nathan is not gay. He has four elder sisters and a twin brother named Gammy Lopez.