Entactin

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Nidogen 1
Protein NID1 PDB 1gl4.png
PDB rendering based on 1gl4.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NID1 ; NID
External IDs OMIM131390 MGI97342 HomoloGene1878 GeneCards: NID1 Gene
RNA expression pattern
PBB GE NID1 202008 s at tn.png
PBB GE NID1 202007 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4811 18073
Ensembl ENSG00000116962 ENSMUSG00000005397
UniProt P14543 P10493
RefSeq (mRNA) NM_002508 NM_010917
RefSeq (protein) NP_002499 NP_035047
Location (UCSC) Chr 1:
236.14 – 236.23 Mb
Chr 13:
13.44 – 13.51 Mb
PubMed search [1] [2]

Entactin also known as nidogen-1 (NID-1) is a protein that in humans is encoded by the NID1 gene.[1][2] Entactin is a component of the basement membrane alongside other components such as collagen type IV, proteoglycans (heparan sulfate and glycosaminoglycans), laminin[3] and fibronectin.[4]

Function[edit]

Entactin is a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes. Structurally it (along with perlecan) connects the networks formed by collagens and laminins to each other.[5] It may also play a role in cell interactions with the extracellular matrix.[6][7]

Interactions[edit]

Entactin has been shown to interact with FBLN1.[8][9][10]

References[edit]

  1. ^ Olsen DR, Nagayoshi T, Fazio M, Mattei MG, Passage E, Weil D, Timpl R, Chu ML, Uitto J (June 1989). "Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome Iq43". Am. J. Hum. Genet. 44 (6): 876–85. PMC 1715653. PMID 2471408. 
  2. ^ Zimmermann K, Hoischen S, Hafner M, Nischt R (May 1995). "Genomic sequences and structural organization of the human nidogen gene (NID)". Genomics 27 (2): 245–50. doi:10.1006/geno.1995.1038. PMID 7557988. 
  3. ^ Smith J, Ockleford CD (January 1994). "Laser scanning confocal examination and comparison of nidogen (entactin) with laminin in term human amniochorion". Placenta 15 (1): 95–106. doi:10.1016/S0143-4004(05)80240-1. PMID 8208674. 
  4. ^ Ockleford CD, Bright N, Hubbard A, D'Lacey C , Smith J, Gardiner L, Sheikh T, Albentosa, M, Turtle K (October 1993). "Micro-Trabeculae, Macro-Plaques or Mini-Basement Membranes in Human Term Fetal Membranes?". Phil. Trans. R. Soc. Lond. B 342 (1300): 121–136. doi:10.1098/rstb.1993.0142. 
  5. ^ Yurchenco PD, Patton BL (2009). "Developmental and pathogenic mechanisms of basement membrane assembly". Curr. Pharm. Des. 15 (12): 1277–94. doi:10.2174/138161209787846766. PMC 2978668. PMID 19355968. 
  6. ^ "Entrez Gene: NID1 nidogen 1". 
  7. ^ Yi XY, Wayner EA, Kim Y, Fish AJ (March 1998). "Adhesion of cultured human kidney mesangial cells to native entactin: role of integrin receptors". Cell Adhes. Commun. 5 (3): 237–48. doi:10.3109/15419069809040294. PMID 9686320. 
  8. ^ Adam S, Göhring W, Wiedemann H, Chu ML, Timpl R, Kostka G (September 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules". J. Mol. Biol. 272 (2): 226–36. doi:10.1006/jmbi.1997.1244. PMID 9299350. 
  9. ^ Tran H, VanDusen WJ, Argraves WS (September 1997). "The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains". J. Biol. Chem. 272 (36): 22600–6. doi:10.1074/jbc.272.36.22600. PMID 9278415. 
  10. ^ Pan TC, Kluge M, Zhang RZ, Mayer U, Timpl R, Chu ML (August 1993). "Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands". Eur. J. Biochem. 215 (3): 733–40. doi:10.1111/j.1432-1033.1993.tb18086.x. PMID 8354280. 

Further reading[edit]

  • Chung AE, Durkin ME (1990). "Entactin: structure and function.". Am. J. Respir. Cell Mol. Biol. 3 (4): 275–82. doi:10.1165/ajrcmb/3.4.275. PMID 2119632. 
  • Yurchenco PD, Schittny JC (1990). "Molecular architecture of basement membranes.". FASEB J. 4 (6): 1577–90. PMID 2180767. 

External links[edit]