Oxalosuccinic acid

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Oxalosuccinic acid
Names
IUPAC name
1-Oxopropane-1,2,3-tricarboxylic acid
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.230.021 Edit this at Wikidata
KEGG
  • InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13) ☒N
    Key: UFSCUAXLTRFIDC-UHFFFAOYSA-N ☒N
  • InChI=1/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)
    Key: UFSCUAXLTRFIDC-UHFFFAOYAK
  • C(C(C(=O)C(=O)O)C(=O)O)C(=O)O
Properties
C6H6O7
Molar mass 190.108
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Oxalosuccinic acid is a substrate of the citric acid cycle. It is acted upon by isocitrate dehydrogenase. Salts and esters of oxalosuccinic acid are known as oxalosuccinates.

Oxalosuccinic acid/Oxalosuccinate is an unstable 6-Carbon intermediate in the TriCarboxylic Acid Cycle. It's an alpha-keto compound, formed during the oxidative decarboxylation of isocitrate to Alpha-Ketoglutarate, which is catalyzed by the enzyme Isocitrate Dehydrogenase. Oxalosuccinate never leaves the active site of the enzyme, however it's unstable and immediately undergoes decarboxylation to produce the 5-carbon compound, Alpha-Ketoglutarate.