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Protocadherin beta 13
Symbols PCDHB13 ; PCDH-BETA13
External IDs OMIM606339 MGI2136752 HomoloGene128504 GeneCards: PCDHB13 Gene
RNA expression pattern
PBB GE PCDHB13 221317 x at tn.png
PBB GE PCDHB3 221408 x at tn.png
PBB GE PCDHB13 221410 x at tn.png
More reference expression data
Species Human Mouse
Entrez 56123 93887
Ensembl ENSG00000187372 ENSMUSG00000047910
UniProt Q9Y5F0 Q91Y03
RefSeq (mRNA) NM_018933 NM_053141.3
RefSeq (protein) NP_061756 NP_444371.3
Location (UCSC) Chr 5:
140.59 – 140.6 Mb
Chr 18:
37.64 – 37.64 Mb
PubMed search [1] [2]

Protocadherin beta-13 is a protein that in humans is encoded by the PCDHB13 gene.[1][2]


This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[2]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHB13 protocadherin beta 13". 

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