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Protocadherin beta 4
External IDs OMIM606330 MGI2136739 HomoloGene75103 GeneCards: PCDHB4 Gene
RNA expression pattern
PBB GE PCDHB11 208504 x at tn.png
PBB GE PCDHB4 221317 x at tn.png
More reference expression data
Species Human Mouse
Entrez 56131 93876
Ensembl ENSG00000081818 ENSMUSG00000063687
UniProt Q9Y5E5 Q8CEA8
RefSeq (mRNA) NM_018938 NM_053130
RefSeq (protein) NP_061761 NP_444360
Location (UCSC) Chr 5:
140.5 – 140.51 Mb
Chr 18:
37.32 – 37.32 Mb
PubMed search [1] [2]

Protocadherin beta-4 is a protein that in humans is encoded by the PCDHB4 gene.[1][2]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[2]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHB4 protocadherin beta 4". 

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