Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CGgene.
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
^Rubio, I; Wittig U; Meyer C; Heinze R; Kadereit D; Waldmann H; Downward J; Wetzker R (November 1999). "Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma". Eur. J. Biochem. (GERMANY) 266 (1): 70–82. doi:10.1046/j.1432-1327.1999.00815.x. ISSN0014-2956. PMID10542052.
^Salgia, R; Sattler M; Pisick E; Li J L; Griffin J D (February 1996). "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". Exp. Hematol. (UNITED STATES) 24 (2): 310–3. ISSN0301-472X. PMID8641358.
^Skorski, T; Kanakaraj P; Nieborowska-Skorska M; Ratajczak M Z; Wen S C; Zon G; Gewirtz A M; Perussia B; Calabretta B (July 1995). "Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells". Blood (UNITED STATES) 86 (2): 726–36. ISSN0006-4971. PMID7606002.