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Phospholipase A2, group V
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PLA2G5 ; FRFB; GV-PLA2; PLA2-10; hVPLA(2)
External IDs OMIM601192 MGI101899 HomoloGene716 IUPHAR: 1430 ChEMBL: 4323 GeneCards: PLA2G5 Gene
EC number
RNA expression pattern
PBB GE PLA2G5 206178 at tn.png
PBB GE PLA2G5 215870 s at tn.png
PBB GE PLA2G5 gnf1h03549 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5322 18784
Ensembl ENSG00000127472 ENSMUSG00000041193
UniProt P39877 P97391
RefSeq (mRNA) NM_000929 NM_001122954
RefSeq (protein) NP_000920 NP_001116426
Location (UCSC) Chr 1:
20.35 – 20.42 Mb
Chr 4:
138.8 – 138.86 Mb
PubMed search [1] [2]

Calcium-dependent phospholipase A2 is an enzyme that in humans is encoded by the PLA2G5 gene.[1][2][3]

This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[3]


  1. ^ Tischfield JA, Xia YR, Shih DM, Klisak I, Chen J, Engle SJ, Siakotos AN, Winstead MV, Seilhamer JJ, Allamand V, Gyapay G, Lusis AJ (Feb 1997). "Low-molecular-weight, calcium-dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and human". Genomics 32 (3): 328–33. doi:10.1006/geno.1996.0126. PMID 8838795. 
  2. ^ Chen J, Engle SJ, Seilhamer JJ, Tischfield JA (Mar 1994). "Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2". J Biol Chem 269 (4): 2365–8. PMID 8300559. 
  3. ^ a b "Entrez Gene: PLA2G5 phospholipase A2, group V". 

Further reading[edit]