PLXNA2

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Plexin A2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PLXNA2 ; OCT; PLXN2
External IDs OMIM601054 MGI107684 HomoloGene56427 GeneCards: PLXNA2 Gene
RNA expression pattern
PBB GE PLXNA2 213030 s at tn.png
PBB GE PLXNA2 207290 at tn.png
PBB GE PLXNA2 gnf1h09338 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5362 18845
Ensembl ENSG00000076356 ENSMUSG00000026640
UniProt O75051 P70207
RefSeq (mRNA) NM_025179 NM_008882
RefSeq (protein) NP_079455 NP_032908
Location (UCSC) Chr 1:
208.2 – 208.42 Mb
Chr 1:
194.62 – 194.82 Mb
PubMed search [1] [2]

Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.[1][2]

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.[2]

In some studies, the PLXNA2 gene is associated with schizophrenia.[3] and anxiety.[4]

References[edit]

  1. ^ Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM (Mar 1996). "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor". Proc Natl Acad Sci USA 93 (2): 674–8. doi:10.1073/pnas.93.2.674. PMC 40111. PMID 8570614. 
  2. ^ a b "Entrez Gene: PLXNA2 plexin A2". 
  3. ^ Gene Overview of All Published Schizophrenia-Association Studies for PLXNA2 - база данных SZGene, сайт Schizophrenia Research Forum
  4. ^ Wray NR, James MR, Mah SP, Nelson M, Andrews G, Sullivan PF, Montgomery GW, Birley AJ, Braun A, Martin NG (March 2007). "Anxiety and comorbid measures associated with PLXNA2". Arch. Gen. Psychiatry 64 (3): 318–26. doi:10.1001/archpsyc.64.3.318. PMID 17339520. 

Further reading[edit]