Pauci-immune (pauci- Latin: few, little) is a general term used to refer to a form of vasculitis that is associated with minimal evidence of hypersensitivity upon immunofluorescence and a lack of Anti-glomerular basement membrane antibody.
They can be associated with antineutrophil cytoplasmic antibodies (ANCA).
In some cases, Pauci-immune crescentic glomerulonephritis is a component of a systemic vasculitis such as Microscopic polyangiitis, Churg–Strauss syndrome or Granulomatosis with polyangiitis. In many cases however, it is limited to the kidney and is thus called idiopathic.
Peak incidences in 50 -60 year olds symptoms include; intermittent fever / weight loss / shortness of breath/ joint pain.