Phyllis Margaret Tookey Kerridge
Phyllis Margaret Tookey Kerridge | |
|---|---|
| Born | Phyllis Margaret Tookey 1901 Bromley, Kent |
| Died | 22 June 1940 |
| Nationality | British |
| Occupation(s) | Physiologist, chemist |
| Years active | 1922–1940 |
| Known for | Inventing the miniature pH electrode Improving the Bragg-Paul pulsator (used for artificial respiration) Developing audiometric standards for hearing tests |
| Notable work | The Use of the Glass Electrode in Biochemistry Principles of physical chemistry for medical students Tests for the hearing of speech by deaf people |
| Spouse | William Kerridge |
Phyllis Margaret Tookey Kerridge (1901–1940) was a chemist and physiologist. She is notable for creating the miniature pH electrode, her work on artificial respiration, and her work on audiometry.
Early life and education
Phyllis Margaret Tookey was born in 1901, the only daughter of William Alfred Tookey of Bromley, Kent.[1] She studied at the City of London School for Girls, where she performed well in science.[2] She then studied chemistry and physics at UCL, obtaining her honours degree in 1922. She completed her PhD, with a thesis on the Use of the Glass Electrode in Biochemistry, in 1927.[1] In 1926, she appears to have married William Kerridge and moved from her family home to St Petersburgh Place.[2] Whilst acting as a lecturer in the UCL department of physiology, she also studied medicine at University College Hospital, qualifying in 1933 and obtaining MRCP in 1937.[1] She was a committee member of the Women's Union Society in her student days.[2]
Scientific career
Kerridge worked at UCL; the Marine Biological Association, Plymouth; the Physiological Laboratory, Cambridge; the Carlsberg Chemical Laboratorium, Copenhagen; the Medical Unit of the London Hospital; the London School of Hygiene and Tropical Medicine, and University College Hospital, London (from which she was seconded by the Emergency Medical Service to St. Margaret's Hospital during the war).
Invention of the miniature pH electrode
In 1925, supported by DSIR and MRC funding, Kerridge published a paper on her invention of a glass electrode for analysing biochemical samples such as blood.[3] For her biochemical PhD research, Kerridge had required a tool small enough to fit into narrow layers in living tissue, but the design of existing pH electrodes was unsuitable because they provided only very small signals. Kerridge overcame this problem by inventing the miniature pH electrode, with a heat-treated platinum component that gave a much larger signal than the older equipment, enabling accurate measurement even in low fluid volumes.[2] Kerridge noted challenges in developing this equipment, including the high resistance of glass, danger of breakage to the delicate apparatus, and risk of short-circuit.[4]
Artificial respiration
After qualifying in medicine in the early 1930s, Kerridge was recommended by Dr Edward Poulton to scientific instrument maker Robert W. Paul, who sought someone to conduct rigorous physiological tests on a respirator called the "pulsator" created by William Henry Bragg.[5] Kerridge's tests provided extensive physiological measurements that improved the efficiency of the device, and she also suggested improvements to the design that reduced its complexity and bulk.[5] Mr S. Crosby Halahan, Bragg's neighbour and the inspiration for his respirator, was kept alive via artificial respiration for two years after becoming completely paralysed - Kerridge adapted the design to make it more comfortable for him.[6][7]
In addition to doing much to improve the design of the respirator, Kerridge also played an active role in publicising it. She had photographs taken of her laboratory assistant wearing the device, advised Bragg and Paul to publish their introduction in the Proceedings of the Royal Society of Medicine, and wrote about the features of the case for The Lancet in order that it would reach the attention of General practitioners.[5][8]
Work on deafness and hearing aids
Later in the 1930s, Kerridge worked at the Royal Ear Hospital and developed audiometric standards for hearing tests.[5] Kerridge also played a significant role in establishing hearing aid clinics for the deaf.[9] Her keen interest in music inspired her sympathy for those with hearing loss.[1][9] This work particularly focussed on the incidence of deafness in children, and she encouraged her students to accompany her on visits to slums to explore potential factors in the etiology of deafness in school-children.[1]
Second World War
At the outbreak of the war, Kerridge was working at University College Hospital. She was seconded from there to serve the Emergency Medical Service at St Margaret's Hospital, Epping. There, Kerridge and her colleagues created an improvised laboratory for work in pathology and blood transfusions.[1]
In 1940, Kerridge died aged 38.
References
- ^ a b c d e f Lovatt Evans, C. (1940). "Dr Phyllis M. Tookey Kerridge" (PDF). Nature. 146 (3692): 159. Bibcode:1940Natur.146..159E. doi:10.1038/146159a0. Retrieved 23 June 2016.
- ^ a b c d Blake-Coleman, Barrie. "Phyllis Kerridge And The Miniature Ph Electrode". Inventricity. Retrieved 26 June 2016.
- ^ Kerridge, Phyllis Margaret Tookey (1925). "The Use of the Glass Electrode in Biochemistry" (PDF). Biochemical Journal. 19 (4): 611–617. doi:10.1042/bj0190611. PMC 1259230. PMID 16743549. Retrieved 23 June 2016.
- ^ Yartsev, Alex. "History of the Glass Electrode". Deranged Physiology. Retrieved 26 June 2016.
- ^ a b c d Virdi-Dhesi, Jaipreet (May 2016). "The Pulsator: How a Portable Artificial Respirator Saved the Lives of Children". From the Hands of Quacks. Retrieved 26 June 2016.
- ^ Science Service (15 April 1934). "Patient Kept Breathing By Football Bladder". New York Times.
{{cite news}}:|access-date=requires|url=(help) - ^ "Briton Succumbs to Rare Malady: He Was Kept Alive Three Years by Breathing Devices That Included Football Bladders". New York Times. 19 February 1936.
{{cite news}}:|access-date=requires|url=(help) - ^ Kerridge, Phyllis Margaret Tookey (1934). "Artificial Respiration for Two Years". The Lancet. 223 (5772): 786–788.
{{cite journal}}:|access-date=requires|url=(help) - ^ a b "Obituaries: Dr Phyllis Kerridge". The Times. London. 26 June 1940. p. 9. Retrieved 26 June 2016.