Plastoquinone

From Wikipedia, the free encyclopedia
  (Redirected from Plastoquinol)
Jump to: navigation, search
Plastoquinone
Plastoquinone.png
Identifiers
CAS number 4299-57-4 YesY
PubChem 6433402
Jmol-3D images Image 1
Properties
Molecular formula C53H80O2
Molar mass 749.20 g mol−1
Related compounds
Related compounds 1,4-benzoquinone quinone Coenzyme Q10
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

Plastoquinone (PQ) is a quinone molecule involved in the electron transport chain in the light-dependent reactions of photosynthesis. Plastoquinone is reduced (accepts two protons (H+) from the stromal matrix of the chloroplast, coupled to two electrons (e-) from photosystem II), forming plastoquinol. It transports the protons to the lumen of thylakoid discs, while the electrons continue through the electron transport chain into the cytochrome b6f protein complex.

The prefix plasto- means either plastid or chloroplast, alluding to its location within the cell.[1]

Structurally it is a 2,3-dimethyl-1,4-benzoquinone molecule with a side chain of nine isoprenyl units.

Derivatives[edit]

Some derivatives designed to penetrate cell membranes (SkQ1 (plastoquinonyl-decyl-triphenylphosphonium), SkQR1 (the rhodamine-containing analog of SkQ1), SkQ3) have anti-oxidant and protonophore activity.[2]

SkQ1 is proposed as an anti-aging treatment.[3][4]

SkQ1 is starting clinical trials for glaucoma in Russia.

See also[edit]

References[edit]

  • Berg, J; Tymoczko, J; Stryer, L (2002). Biochemistry (Fifth Edition). W H Freeman and Company. ISBN 0-7167-4684-0. 
  1. ^ http://dictionary.reference.com/browse/Plastoquinone Definition of plastoquinone
  2. ^ F.F. Severina; I.I. Severina, Y.N. Antonenkoa, T.I. Rokitskayaa, D.A. Cherepanovb, E.N. Mokhovaa, M.Yu. Vyssokikha, A.V. Pustovidkoa, O.V. Markovaa, L.S. Yaguzhinskya, G.A. Korshunovaa, N.V. Sumbatyana, M.V. Skulacheva, V.P. Skulacheva (2009). "Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore.". Proc. Natl. Acad. Sci. U.S.A. 107 (2): 663–8. doi:10.1073/pnas.0910216107. PMC 2818959. PMID 20080732. 
  3. ^ "An attempt to prevent senescence: A mitochondrial approach.". 2008. 
  4. ^ http://protein.bio.msu.ru/biokhimiya/contents/v73/pdf/bcm_1329.pdf Mitochondria-Targeted Plastoquinone Derivatives as Tools to Interrupt Execution of the Aging Program. 5. SkQ1 Prolongs Lifespan and Prevents Development of Traits of Senescence. Anisimov etal. 2008

External links[edit]