RCBTB2
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| Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | |||||||||
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| Identifiers | |||||||||
| Symbols | RCBTB2; CHC1L | ||||||||
| External IDs | OMIM: 603524 MGI: 1917200 HomoloGene: 970 GeneCards: RCBTB2 Gene | ||||||||
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| RNA expression pattern | |||||||||
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| More reference expression data | |||||||||
| Orthologs | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | 1102 | 105670 | |||||||
| Ensembl | ENSG00000136161 | ENSMUSG00000022106 | |||||||
| UniProt | O95199 | Q99LJ7 | |||||||
| RefSeq (mRNA) | NM_001268.2 | NM_001170694.1 | |||||||
| RefSeq (protein) | NP_001259.1 | NP_001164165.1 | |||||||
| Location (UCSC) | Chr 13: 49.06 – 49.11 Mb |
Chr 14: 73.52 – 73.61 Mb |
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| PubMed search | [1] | [2] | |||||||
RCC1 and BTB domain-containing protein 2 is a protein that in humans is encoded by the RCBTB2 gene.[1][2]
This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.[2]
[edit] References
- ^ Devilder MC, Cadoret E, Cherel M, Moreau I, Rondeau G, Bezieau S, Moisan JP (Jan 1999). "cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor". Genomics 54 (1): 99–106. doi:10.1006/geno.1998.5498. PMID 9806834.
- ^ a b "Entrez Gene: RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1102.
[edit] Further reading
- Rual JF, Venkatesan K, Hao T et al (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Dunham A, Matthews LH, Burton J et al (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665288.
- Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Latil A, Morant P, Fournier G et al (2002). "CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer". Int. J. Cancer 99 (5): 689–96. doi:10.1002/ijc.10393. PMID 12115502.
- Renault L, Nassar N, Wittinghofer A et al (1999). "Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation". Acta Crystallogr. D Biol. Crystallogr. 55 (Pt 1): 272–5. doi:10.1107/S0907444998007768. PMID 10089422.
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