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Ring finger protein 111
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RNF111 ; ARK
External IDs OMIM605840 MGI1934919 HomoloGene9741 GeneCards: RNF111 Gene
EC number 6.3.2.-
RNA expression pattern
PBB GE RNF111 218761 at tn.png
More reference expression data
Species Human Mouse
Entrez 54778 93836
Ensembl ENSG00000157450 ENSMUSG00000032217
UniProt Q6ZNA4 Q99ML9
RefSeq (mRNA) NM_001270528 NM_033604
RefSeq (protein) NP_001257457 NP_291082
Location (UCSC) Chr 15:
59.16 – 59.39 Mb
Chr 9:
70.43 – 70.5 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.[1][2]

The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.[2]


RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7[3] and Mothers against decapentaplegic homolog 3.[3][4]


  1. ^ Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D (Apr 2001). "Induction of the mammalian node requires Arkadia function in the extraembryonic lineages". Nature 410 (6830): 825–30. doi:10.1038/35071095. PMID 11298452. 
  2. ^ a b "Entrez Gene: RNF111 ring finger protein 111". 
  3. ^ a b Koinuma, Daizo; Shinozaki Masahiko, Komuro Akiyoshi, Goto Kouichiro, Saitoh Masao, Hanyu Aki, Ebina Masahito, Nukiwa Toshihiro, Miyazawa Keiji, Imamura Takeshi, Miyazono Kohei (Dec 2003). "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7". EMBO J. (England) 22 (24): 6458–70. doi:10.1093/emboj/cdg632. ISSN 0261-4189. PMC 291827. PMID 14657019. 
  4. ^ Yuzawa, Hisanori; Koinuma Daizo; Maeda Shingo; Yamamoto Kengo; Miyazawa Keiji; Imamura Takeshi (Jan 2009). "Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts". Bone (United States) 44 (1): 53–60. doi:10.1016/j.bone.2008.09.013. PMID 18950738. 

Further reading[edit]