E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111gene.
The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.
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Nagano Y, Mavrakis KJ, Lee KL et al. (2007). "Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling". J. Biol. Chem.282 (28): 20492–501. doi:10.1074/jbc.M701294200. PMID17510063.CS1 maint: Explicit use of et al. (link)