Rosenthal fiber

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Rosenthal fibers.
H&E staining showing these elongated eosinophilic structures in a case of pilocytic astrocytoma. Magnification 400x

A Rosenthal fiber is a thick, elongated, worm-like or "corkscrew" eosinophilic (pink) bundle that is found on H&E staining of the brain in the presence of long standing gliosis, occasional tumors, and some metabolic disorders.

Associated conditions[edit]

Its presence is associated with either pilocytic astrocytoma[1] (more common) or Alexander's disease (a rare leukodystrophy). They are also seen in the context of fucosidosis.

Pilocytic astrocytoma is the most common primitive tumor in pediatric patients.

Composition[edit]

The fibers are found in astrocytic processes and are thought to be clumped intermediate filament proteins.

Their components include glial fibrillary acidic protein.[2]

References[edit]

  1. ^ Wippold FJ, Perry A, Lennerz J (May 2006). "Neuropathology for the neuroradiologist: Rosenthal fibers". AJNR Am J Neuroradiol 27 (5): 958–61. PMID 16687524. 
  2. ^ Tanaka KF, Ochi N, Hayashi T, Ikeda E, Ikenaka K (October 2006). "Fluoro-Jade: new fluorescent marker of Rosenthal fibers". Neurosci. Lett. 407 (2): 127–30. doi:10.1016/j.neulet.2006.08.014. PMID 16949206. 

External links[edit]