Rostral interstitial nucleus of medial longitudinal fasciculus

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Brain: Rostral interstitial nucleus of medial longitudinal fasciculus

Coronal section through mid-brain. (Nucleus is not labeled, but MLF is "b", in red.)
Latin	nucleus interstitialis
NeuroNames	hier-507
NeuroLex ID	birnlex_1481

The rostral interstitial nucleus of medial longitudinal fasciculus (riMLF) is a portion of the medial longitudinal fasciculus which controls vertical gaze.

They project to the vestibular nuclei.

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Human brain: mesencephalon (midbrain) (TA A14.1.06, GA 9.800)

Tectum (Dorsal)

Surface	Corpora quadrigemina: Inferior colliculi (Brachium of inferior colliculus), Superior colliculi (Brachium of superior colliculus)

Grey matter	Pretectal area

White: Sensory/ascending	Spinotectal tract · Central tegmental tract

White: Motor/descending	Tectospinal tract

Peduncle (Ventral)

Peduncle tegmentum

White: Sensory/ascending	lemnisci (Medial, Lateral) · Ascending MLF (Vestibulo-oculomotor fibers) · Spinothalamic tract · Anterior trigeminothalamic tract · Dentatothalamic tract

White: Motor/descending	Rubrospinal tract · Rubro-olivary tract · Descending MLF

Grey: cranial nuclei	GSA (V: Mesencephalic) - GSE (III: Oculomotor, IV: Trochlear) - GVE (III: Edinger-Westphal)

Grey: other	Periaqueductal gray/Raphe nuclei (Dorsal raphe nucleus) Ventral tegmental area • Pedunculopontine nucleus • Red nucleus riMLF

Ventricular system	Cerebral aqueduct

Peduncle base

White: Motor/descending	Cerebral crus: Corticospinal tract · Corticobulbar tract · Corticopontine tract/Frontopontine fibers/Temporopontine fibers

Grey: Substantia nigra	Pars compacta · Pars reticulata

Surface	Superior cerebellar peduncle (Decussation of superior cerebellar peduncles) · Interpeduncular fossa

Sensory system: Visual system and eye movement pathways

Visual perception

1° (Bipolar cell of Retina) → 2° (Ganglionic cell) → 3° (Optic nerve → Optic chiasm → Optic tract → LGN of Thalamus) → 4° (Optic radiation → Cuneus and Lingual gyrus of Visual cortex → Blobs → Globs)

Muscles of orbit

Tracking	Smooth pursuit: Parietal lobe · Occipital lobe Saccade: Frontal eye fields Physiologic nystagmus → Fixation reflex → PPRF

Horizontal gaze	PPRF → Abducens nucleus → MLF → Oculomotor nucleus → Medial rectus muscle

Vertical gaze	Rostral interstitial nucleus → Oculomotor nucleus, Trochlear nucleus → Muscles of orbit

Vestibulo-ocular reflex	Semicircular canal → Vestibulocochlear nerve → Vestibular nuclei → Abducens nucleus → MLF (Vestibulo-oculomotor fibers) → Oculomotor nucleus → Medial rectus muscle

Pupillary reflex

Pupillary dilation	1° (Posterior hypothalamus → Ciliospinal center) → 2° (Superior cervical ganglion) → 3° (Sympathetic root of ciliary ganglion → Nasociliary nerve → Long ciliary nerves → Iris dilator muscle)

Pupillary light reflex (constriction)	1° (Retina → Optic nerve → Optic chiasm → Optic tract → Pretectal nucleus) → 2° (Edinger-Westphal nucleus) → 3° (Oculomotor nerve → Parasympathetic root of ciliary ganglion → Ciliary ganglion) → (4° Short ciliary nerves → Iris sphincter muscle)

Accommodation vergence	1° (Retina → Optic nerve → Optic chiasm → Optic tract → Visual cortex → Brodmann area 19 → Pretectal area) → 2° (Edinger-Westphal nucleus) → 3° (Short ciliary nerves → Ciliary ganglion → Ciliary muscle)