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SH3 and PX domains 2A
Protein SH3PXD2A PDB 2DNU.png
Rendering based on PDB 2DNU.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SH3PXD2A ; FISH; SH3MD1; TKS5
External IDs MGI1298393 HomoloGene7317 GeneCards: SH3PXD2A Gene
RNA expression pattern
PBB GE SH3PXD2A 207661 s at tn.png
PBB GE SH3PXD2A 213252 at tn.png
More reference expression data
Species Human Mouse
Entrez 9644 14218
Ensembl ENSG00000107957 ENSMUSG00000053617
UniProt Q5TCZ1 O89032
RefSeq (mRNA) NM_014631 NM_001164717
RefSeq (protein) NP_055446 NP_001158189
Location (UCSC) Chr 10:
105.35 – 105.62 Mb
Chr 19:
47.26 – 47.46 Mb
PubMed search [1] [2]

SH3 and PX domain-containing protein 2A is a protein that in humans is encoded by the SH3PXD2A gene.[1][2]


Further reading[edit]

  • Ishikawa K, Nagase T, Nakajima D et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477. 
  • Abram CL, Seals DF, Pass I et al. (2003). "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells.". J. Biol. Chem. 278 (19): 16844–51. doi:10.1074/jbc.M300267200. PMID 12615925. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Brandenberger R, Wei H, Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
  • Deloukas P, Earthrowl ME, Grafham DV et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
  • Seals DF, Azucena EF, Pass I et al. (2005). "The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells.". Cancer Cell 7 (2): 155–65. doi:10.1016/j.ccr.2005.01.006. PMID 15710328. 
  • Malinin NL, Wright S, Seubert P et al. (2005). "Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity.". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 3058–63. doi:10.1073/pnas.0408237102. PMC 549444. PMID 15710903. 
  • Harold D, Jehu L, Turic D et al. (2007). "Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 448–52. doi:10.1002/ajmg.b.30456. PMID 17440933.