SLURP1

SLURP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MUP, 2MUO
Identifiers
Aliases	SLURP1, ANUP, ARS, ArsB, LY6LS, MDM, secreted LY6/PLAUR domain containing 1, LY6-MT
External IDs	OMIM: 606119; MGI: 1930923; HomoloGene: 10710; GeneCards: SLURP1; OMA:SLURP1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q24.3 Start 142,740,949 bp End 142,742,406 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 D3 Start 74,596,167 bp End 74,599,883 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in human penis skin of abdomen oral cavity body of tongue vulva gums cervix epithelium epithelium of esophagus nipple vagina Top expressed in lip esophagus pyloric antrum mucous cell of stomach cornea cervix ankle spermatocyte atrioventricular valve epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity acetylcholine receptor activator activity protein binding Cellular component extracellular exosome extracellular space extracellular region Biological process cell adhesion negative regulation of keratinocyte proliferation neuromuscular process controlling posture locomotory behavior cell activation negative regulation of cell population proliferation negative regulation of cell migration urokinase plasminogen activator signaling pathway positive regulation of signaling receptor activity regulation of signaling receptor activity regulation of neurotransmitter receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57152 57277 Ensembl ENSG00000126233 ENSMUSG00000022596 UniProt P55000 Q9Z0K7 RefSeq (mRNA) NM_020427 NM_020519 RefSeq (protein) NP_065160 NP_065265 Location (UCSC) Chr 8: 142.74 – 142.74 Mb Chr 15: 74.6 – 74.6 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Secreted Ly-6/uPAR-related protein 1 is a protein that in humans is encoded by the SLURP1 gene.

Function

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.

Further reading

• Ridge RJ, Sloane NH (January 1996). "Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes". Cytokine. 8 (1): 1–5. doi:10.1006/cyto.1996.0001. PMID 8742060.
• Fischer J, Bouadjar B, Heilig R, Fizames C, Prud'homme JF, Weissenbach J (1999). "Genetic linkage of Meleda disease to chromosome 8qter". European Journal of Human Genetics. 6 (6): 542–7. doi:10.1038/sj.ejhg.5200254. PMID 9887370.
• Eckl KM, Stevens HP, Lestringant GG, Westenberger-Treumann M, Traupe H, Hinz B, Frossard PM, Stadler R, Leigh IM, Nürnberg P, Reis A, Hennies HC (January 2003). "Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates". Human Genetics. 112 (1): 50–6. doi:10.1007/s00439-002-0838-8. PMID 12483299.
• Marrakchi S, Audebert S, Bouadjar B, Has C, Lefèvre C, Munro C, Cure S, Jobard F, Morlot S, Hohl D, Prud'homme JF, Zahaf A, Turki H, Fischer J (March 2003). "Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda". The Journal of Investigative Dermatology. 120 (3): 351–5. doi:10.1046/j.1523-1747.2003.12062.x. PMID 12603845.
• Hu G, Yildirim M, Baysal V, Yerebakan O, Yilmaz E, Inaloz HS, Martinez-Mir A, Christiano AM, Celebi JT (June 2003). "A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect". The Journal of Investigative Dermatology. 120 (6): 967–9. doi:10.1046/j.1523-1747.2003.12248.x. PMID 12787122.
• Chimienti F, Hogg RC, Plantard L, Lehmann C, Brakch N, Fischer J, Huber M, Bertrand D, Hohl D (November 2003). "Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda". Human Molecular Genetics. 12 (22): 3017–24. doi:10.1093/hmg/ddg320. PMID 14506129.
• Charfeddine C, Mokni M, Ben Mousli R, Elkares R, Bouchlaka C, Boubaker S, Ghedamsi S, Baccouche D, Ben Osman A, Dellagi K, Abdelhak S (December 2003). "A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia". The British Journal of Dermatology. 149 (6): 1108–15. doi:10.1111/j.1365-2133.2003.05606.x. PMID 14674887.
• Mastrangeli R, Donini S, Kelton CA, He C, Bressan A, Milazzo F, Ciolli V, Borrelli F, Martelli F, Biffoni M, Serlupi-Crescenzi O, Serani S, Micangeli E, El Tayar N, Vaccaro R, Renda T, Lisciani R, Rossi M, Papoian R (2004). "ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda". European Journal of Dermatology. 13 (6): 560–70. PMID 14721776.
• Mokni M, Charfeddine C, Ben Mously R, Baccouche D, Kaabi B, Ben Osman A, Dellagi K, Abdelhak S (March 2004). "Heterozygous manifestations in female carriers of Mal de Meleda". Clinical Genetics. 65 (3): 244–6. doi:10.1111/j.0009-9163.2004.00224.x. PMID 14756676.
• Chao SC, Lai FJ, Yang MH, Lee JY (April 2005). "Mal de Meleda in a taiwanese". Journal of the Formosan Medical Association = Taiwan Yi Zhi. 104 (4): 276–8. PMID 15909066.
• Arredondo J, Chernyavsky AI, Webber RJ, Grando SA (December 2005). "Biological effects of SLURP-1 on human keratinocytes". The Journal of Investigative Dermatology. 125 (6): 1236–41. doi:10.1111/j.0022-202X.2005.23973.x. PMID 16354194.
• Arredondo J, Chernyavsky AI, Grando SA (October 2007). "Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells". Biochemical Pharmacology. 74 (8): 1315–9. doi:10.1016/j.bcp.2007.06.026. PMC 2046218. PMID 17643396.