SOS box

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SOS box is the region in the promoter of various genes to which the LexA repressor binds to repress the transcription in the absence of DNA damage.

Examples[edit]

Phylogenetic Clade Sequence Reference
Alpha Proteobacteria GAAC(N)7GAAC
GTTC(N)7GTTC
[1][2]
Betaproteobacteria
Gammaproteobacteria
CTGT(N)8ACAG [3]
Deltaproteobacteria CTRHAMRYBYGTTCAGS [4]
Gram-positive Bacteria CGAACRNRYGTTYC [5][6]
Cyanobacteria RGTAC(N)3DGTWCB [7]

See Nucleic acid nomenclature for an explanation of non-GATC nucleotide letters

See also[edit]

References[edit]

  1. ^ Fernández de Henestrosa AR, Rivera E, Tapias A, Barbé J (June 1998). "Identification of the Rhodobacter sphaeroides SOS box". Mol. Microbiol. 28 (5): 991–1003. doi:10.1046/j.1365-2958.1998.00860.x. PMID 9663685. 
  2. ^ Tapias A, Barbé J (August 1999). "Regulation of divergent transcription from the uvrA-ssb promoters in Sinorhizobium meliloti". Mol. Gen. Genet. 262 (1): 121–30. doi:10.1007/s004380051066. PMID 10503543. 
  3. ^ Erill I, Escribano M, Campoy S, Barbé J (November 2003). "In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon". Bioinformatics 19 (17): 2225–36. doi:10.1093/bioinformatics/btg303. PMID 14630651. 
  4. ^ Campoy S, Fontes M, Padmanabhan S, Cortés P, Llagostera M, Barbé J (August 2003). "LexA-independent DNA damage-mediated induction of gene expression in Myxococcus xanthus". Mol. Microbiol. 49 (3): 769–81. doi:10.1046/j.1365-2958.2003.03592.x. PMID 12864858. 
  5. ^ Winterling KW, Chafin D, Hayes JJ, et al. (15 April 1998). "The Bacillus subtilis DinR Binding Site: Redefinition of the Consensus Sequence". J. Bacteriol. 180 (8): 2201–11. PMC 107149. PMID 9555905. 
  6. ^ Davis EO, Dullaghan EM, Rand L (June 2002). "Definition of the Mycobacterial SOS Box and Use To Identify LexA-Regulated Genes in Mycobacterium tuberculosis". J. Bacteriol. 184 (12): 3287–95. doi:10.1128/JB.184.12.3287-3295.2002. PMC 135081. PMID 12029045. 
  7. ^ Mazón G, Lucena JM, Campoy S, Fernández de Henestrosa AR, Candau P, Barbé J (February 2004). "LexA-binding sequences in Gram-positive and cyanobacteria are closely related". Mol. Genet. Genomics 271 (1): 40–9. doi:10.1007/s00438-003-0952-x. PMID 14652736.