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Sulfatase 2
Symbols SULF2 ; HSULF-2
External IDs OMIM610013 MGI1919293 HomoloGene10313 GeneCards: SULF2 Gene
Species Human Mouse
Entrez 55959 72043
Ensembl ENSG00000196562 ENSMUSG00000006800
UniProt Q8IWU5 Q8CFG0
RefSeq (mRNA) NM_001161841 NM_001252578
RefSeq (protein) NP_001155313 NP_001239507
Location (UCSC) Chr 20:
46.29 – 46.42 Mb
Chr 2:
166.07 – 166.16 Mb
PubMed search [1] [2]

Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.[1][2]

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM][2]


  1. ^ Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD (Dec 2002). "Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans". J Biol Chem 277 (51): 49175–85. doi:10.1074/jbc.M205131200. PMC 2779716. PMID 12368295. 
  2. ^ a b "Entrez Gene: SULF2 sulfatase 2". 

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