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SULT1C2

From Wikipedia, the free encyclopedia
SULT1C2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSULT1C2, ST1C1, ST1C2, SULT1C1, humSULTC2, sulfotransferase family 1C member 2
External IDsOMIM: 602385; MGI: 1916333; HomoloGene: 38201; GeneCards: SULT1C2; OMA:SULT1C2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001056
NM_176825

NM_026935

RefSeq (protein)

NP_001047
NP_789795

NP_081211

Location (UCSC)Chr 2: 108.29 – 108.31 MbChr 17: 54.14 – 54.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sulfotransferase 1C2 is an enzyme that in humans is encoded by the SULT1C2 gene.[5][6][7]

Function

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Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198203Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023122Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Her C, Kaur GP, Athwal RS, Weinshilboum RM (May 1997). "Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization". Genomics. 41 (3): 467–70. doi:10.1006/geno.1997.4683. PMID 9169148.
  6. ^ Freimuth RR, Raftogianis RB, Wood TC, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM (April 2000). "Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization". Genomics. 65 (2): 157–65. doi:10.1006/geno.2000.6150. PMID 10783263.
  7. ^ a b "Entrez Gene: SULT1C1 sulfotransferase family, cytosolic, 1C, member 1".

Further reading

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