The Chicago-born artist attracted attention when he was named Down Beat magazine's Collegiate Jazz Vocalist of the Year in 1999. He has worked with the Lincoln Center Jazz Orchestra with Wynton Marsalis. His debut recording, Eyes Wide Open, lead to tours and opening for artists such as jazz trumpeter Chris Botti and pop singer Joan Osborne. Vasandani's second album, 2009's We Move, was chosen as a New York Times Critic's Pick.
In a September 20, 2009, review in The New York Times, Nate Chinen called Vasandani "a jazz singer with good ideas, including some about what a jazz singer can be."
In a review of Eyes Wide Open, The Boston Globe suggested that Vasandani is "mature in sound and rich in texture but also possesses enough youthful angst in its lyrical themes to ward off the fogeyism that male vocalists so easily slip into before their time."
Vasandani has toured internationally. In 2009 Vasandani performed in New York, California and Washington, as well as in Switzerland, Germany and Russia.