San Francisco de los Romo is a municipality in the Mexican state of Aguascalientes. It stands at 22°05′N 102°16′W / 22.083°N 102.267°W in the central part of the state.
The municipality, which has an area of 139.54 km², reported a 2010 Census population of 35,769. It is located in the middle of the Aguascalientes Valley, at 20 km towards north from the state capital Aguascalientes; it adjoins with the municipalities of Pabellón de Arteaga and Asientos to the north, Jesús María to the west, and Aguascalientes to the south-east.
The town of San Francisco de los Romo, which is the sixth-largest community in the state, is located at the northwest corner of the municipality and serves as its municipal seat.