Sarcospan

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sarcospan
Identifiers
Symbol SSPN
Entrez 8082
HUGO 11322
OMIM 601599
Other data
Locus Chr. 12 p11.2

Sarcospan, discovered by the research group of Kevin Campbell, is a 25-kDa transmembrane protein located in the dystrophin-associated protein complex of skeletal muscle cells. It contains four transmembrane spanning helices with both N- and C-terminal domains located intracellularly.[1] Loss of sarcospan expression occurs in patients with Duchenne muscular dystrophy, indicating that dystrophin is required for proper localization of sarcospan.[1] Sarcospan knockout mice exhibit normal muscle structure and function, indicating that sarcospan is not necessary for muscle to develop.[2]

References[edit]

  1. ^ a b Crosbie et al.; Heighway, J; Venzke, DP; Lee, JC; Campbell, KP (1997). "Sarcospan, the 25-kDa transmembrane component of the dystrophin-glycoprotein complex". J Biol Chem 272 (50): 31221–4. doi:10.1074/jbc.272.50.31221. PMID 9395445. 
  2. ^ Lebakken et al.; Venzke, DP; Hrstka, RF; Consolino, CM; Faulkner, JA; Williamson, RA; Campbell, KP (2000). "Sarcospan-deficient mice maintain normal muscle function.". Mol Cell Biol 20 (5): 1669–77. doi:10.1128/MCB.20.5.1669-1677.2000. PMC 85350. PMID 10669744. 

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