Sarcospan, discovered by the research group of Kevin Campbell, is a 25-kDa transmembrane protein located in the dystrophin-associated protein complex of skeletal muscle cells. It contains four transmembrane spanning helices with both N- and C-terminal domains located intracellularly. Loss of sarcospan expression occurs in patients with Duchenne muscular dystrophy, indicating that dystrophin is required for proper localization of sarcospan. Sarcospan knockout mice exhibit normal muscle structure and function, indicating that sarcospan is not necessary for muscle to develop.
- ^ a b Crosbie et al.; Heighway, J; Venzke, DP; Lee, JC; Campbell, KP (1997). "Sarcospan, the 25-kDa transmembrane component of the dystrophin-glycoprotein complex". J Biol Chem 272 (50): 31221–4. doi:10.1074/jbc.272.50.31221. PMID 9395445.
- ^ Lebakken et al.; Venzke, DP; Hrstka, RF; Consolino, CM; Faulkner, JA; Williamson, RA; Campbell, KP (2000). "Sarcospan-deficient mice maintain normal muscle function.". Mol Cell Biol 20 (5): 1669–77. doi:10.1128/MCB.20.5.1669-1677.2000. PMC 85350. PMID 10669744.