The name is derived from the Latin Sextum, a small village that was likely founded in the second century A.D., where stones were assembled for the Roman road that left from Genoa. No physical records exist about the population of Sestri before the fifteenth century.
The links to the transport sector continue to this day; Sestri Ponente is home to Genoa Cristoforo Colombo Airport. Another major source of employment are the shipyards, part of the Merchant Ships Business Unit of Fincantieri. They are currently enjoying the benefits of the current ship construction boom after the blows felt from the 1970s to the 1990s.