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St Columb may refer to:
- St Columb's Cathedral, Derry
- St Columb's College, Derry
- St Columb Canal
- St Columb Major
- St Columb Minor
- St Columb Road
- Lady Dona St Columb, a character in Frenchman's Creek by Daphne du Maurier
- The Monastery of St Columb, a book by Regina Maria Roche
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