Stauffer syndrome

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Stauffer syndrome
Classification and external resources
DiseasesDB 29132

Stauffer syndrome is a constellation of signs and symptoms of liver dysfunction that arise due to presence of renal cell carcinoma, and, more rarely, in connection with other malignant neoplasms. It is named for Dr. Maurice Stauffer, a gastroenterologist at the Mayo Clinic in Rochester, MN. The hepatic abnormalities are not due to tumor infiltration of the liver or intrinsic liver disease; they instead reflect the presence of a paraneoplastic syndrome.[1]

Stauffer syndrome causes abnormal liver function tests, especially those that reflect the presence of cholestasis, i.e. abnormal bile flow. The symptoms and signs resolve if the renal cell carcinoma (or another associated tumor) is successfully ablated.[1]


Maurice H. Stauffer, M.D., a gastroenterologist at the Mayo Clinic in Rochester, MN, first characterized this syndrome in 1961, with the original name of "nephrogenic hepatomegaly."[2][3]


  1. ^ a b Jakse G, Madersbacher H (1978). "[Stauffer's syndrome. Reversible hepatic dysfunction in renal cell carcinoma (author's transl)]". Wien Klin Wochenschr 90 (8): 268–70. PMID 636440. 
  2. ^ Stauffer MH (1961). "Nephrogenic hepatomegaly". Gastroenterology 40: 694. 
  3. ^ Morla D, Alazemi S, Lichtstein D (July 2006). "Stauffer's Syndrome Variant with Cholestatic Jaundice A Case Report". J Gen Intern Med 21 (7): C11–3. doi:10.1111/j.1525-1497.2006.00448.x. PMC 1924715. PMID 16808761.