From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protein TAGLN PDB 1ujo.png
PDB rendering based on 1ujo.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TAGLN ; SM22; SMCC; TAGLN1; WS3-10
External IDs OMIM600818 MGI106012 HomoloGene2398 GeneCards: TAGLN Gene
RNA expression pattern
PBB GE TAGLN 205547 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6876 21345
Ensembl ENSG00000149591 ENSMUSG00000032085
UniProt Q01995 P37804
RefSeq (mRNA) NM_001001522 NM_011526
RefSeq (protein) NP_001001522 NP_035656
Location (UCSC) Chr 11:
117.07 – 117.08 Mb
Chr 9:
45.93 – 45.94 Mb
PubMed search [1] [2]

Transgelin is a protein that in humans is encoded by the TAGLN gene.[1][2][3]

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.[3]


  1. ^ Kobayashi R, Kubota T, Hidaka H (Mar 1994). "Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog". Biochem Biophys Res Commun 198 (3): 1275–80. doi:10.1006/bbrc.1994.1180. PMID 8117285. 
  2. ^ Thweatt R, Lumpkin CK Jr, Goldstein S (Oct 1992). "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts". Biochem Biophys Res Commun 187 (1): 1–7. doi:10.1016/S0006-291X(05)81449-4. PMID 1520290. 
  3. ^ a b "Entrez Gene: TAGLN transgelin". 

Further reading[edit]