Transgelin

TAGLN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UJO
Identifiers
Aliases	TAGLN, SM22, SMCC, TAGLN1, WS3-10, transgelin, SM22-alpha
External IDs	OMIM: 600818 MGI: 106012 HomoloGene: 2398 GeneCards: TAGLN
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 117,199,370 bp End 117,207,464 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 A5.2|9 25.36 cM Start 45,840,917 bp End 45,847,356 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein popliteal artery right coronary artery ascending aorta left coronary artery myometrium urethra vena cava left uterine tube gastric mucosa Top expressed in ascending aorta belly cord cervix aortic valve seminal vesicula left colon calvaria gallbladder pyloric antrum external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding actin binding actin filament binding Cellular component cytoplasm Biological process muscle organ development epithelial cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6876 21345 Ensembl ENSG00000149591 ENSMUSG00000032085 UniProt Q01995 P37804 RefSeq (mRNA) NM_003186 NM_001001522 NM_011526 RefSeq (protein) NP_001001522 NP_003177 NP_035656 Location (UCSC) Chr 11: 117.2 – 117.21 Mb Chr 9: 45.84 – 45.85 Mb PubMed search
Wikidata
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Transgelin is a protein that in humans is encoded by the TAGLN gene.

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.

Further reading

• Nishida W, Kitami Y, Abe M, Hiwada K (1991). "Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle". Biochem. Int. 23 (4): 663–8. PMID 1872880.
• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1" (PDF). DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Li L, Liu Z, Mercer B, et al. (1997). "Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells". Dev. Biol. 187 (2): 311–21. doi:10.1006/dbio.1997.8621. PMID 9242426.
• Yamamura H, Masuda H, Ikeda W, et al. (1997). "Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation". J. Biochem. 122 (1): 157–67. doi:10.1093/oxfordjournals.jbchem.a021722. PMID 9276683.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Lawson D, Harrison M, Shapland C (1998). "Fibroblast transgelin and smooth muscle SM22alpha are the same protein, the expression of which is down-regulated in many cell lines". Cell Motil. Cytoskeleton. 38 (3): 250–7. doi:10.1002/(SICI)1097-0169(1997)38:3<250::AID-CM3>3.0.CO;2-9. PMID 9384215.
• Camoretti-Mercado B, Forsythe SM, LeBeau MM, et al. (1998). "Expression and cytogenetic localization of the human SM22 gene (TAGLN)". Genomics. 49 (3): 452–7. doi:10.1006/geno.1998.5267. PMID 9615232.
• Fu Y, Liu HW, Forsythe SM, et al. (2001). "Mutagenesis analysis of human SM22: characterization of actin binding". J. Appl. Physiol. 89 (5): 1985–90. doi:10.1152/jappl.2000.89.5.1985. PMID 11053353. S2CID 1573662.
• Shields JM, Rogers-Graham K, Der CJ (2002). "Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways". J. Biol. Chem. 277 (12): 9790–9. doi:10.1074/jbc.M110086200. PMID 11773051.
• Chainiaux F, Magalhaes JP, Eliaers F, et al. (2002). "UVB-induced premature senescence of human diploid skin fibroblasts". Int. J. Biochem. Cell Biol. 34 (11): 1331–9. doi:10.1016/S1357-2725(02)00022-5. PMID 12200029.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Xu R, Ho YS, Ritchie RP, Li L (2003). "Human SM22 alpha BAC encompasses regulatory sequences for expression in vascular and visceral smooth muscles at fetal and adult stages". Am. J. Physiol. Heart Circ. Physiol. 284 (4): H1398–407. doi:10.1152/ajpheart.00737.2002. PMID 12521938.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Yang Z, Chang YJ, Miyamoto H, et al. (2007). "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth". Mol. Endocrinol. 21 (2): 343–58. doi:10.1210/me.2006-0104. PMID 17082327.
• Liao X, Li S, Lou Z, et al. (2007). "Crystallization and preliminary crystallographic analysis of transgelin". Protein Pept. Lett. 14 (2): 209–11. doi:10.2174/092986607779816122. PMID 17305610.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.