TNPO2

TNPO2
Identifiers
Aliases	TNPO2, IPO3, KPNB2B, TRN2, transportin 2
External IDs	OMIM: 603002 MGI: 2384849 HomoloGene: 8381 GeneCards: TNPO2
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.13 Start 12,699,194 bp End 12,724,011 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C3 Start 85,763,544 bp End 85,784,212 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior olivary nucleus entorhinal cortex pons Brodmann area 46 nipple ventral tegmental area superior vestibular nucleus orbitofrontal cortex parietal lobe external globus pallidus Top expressed in entorhinal cortex visual cortex corneal stroma superior frontal gyrus cingulate gyrus lip yolk sac spermatocyte primary motor cortex cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear localization sequence binding Cellular component nuclear membrane nuclear periphery nucleus cytoplasm Biological process protein transport intracellular protein transport ribosomal protein import into nucleus NLS-bearing protein import into nucleus protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30000 212999 Ensembl ENSG00000105576 ENSMUSG00000031691 UniProt O14787 Q99LG2 RefSeq (mRNA) NM_013433 NM_001136195 NM_001136196 NM_001122843 NM_145390 NM_001364031 NM_001364032 NM_001364033 NM_001364034 NM_001379096 RefSeq (protein) NP_001129667 NP_001129668 NP_038461 NP_001369165 NP_001369166 NP_001369167 NP_001369168 NP_001369169 NP_001369170 NP_001369171 NP_001369172 NP_001129667.1 NP_038461.2 NP_001116315 NP_663365 NP_001350960 NP_001350961 NP_001350962 NP_001350963 NP_001366025 Location (UCSC) Chr 19: 12.7 – 12.72 Mb Chr 8: 85.76 – 85.78 Mb PubMed search
Wikidata
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Transportin-2 is a protein that in humans is encoded by the TNPO2 gene.

Interactions

TNPO2 has been shown to interact with NXF1, NUP98 and Ran (biology).

Further reading

• Gallouzi IE, Steitz JA (November 2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science. 294 (5548): 1895–901. Bibcode:2001Sci...294.1895G. doi:10.1126/science.1064693. PMID 11729309. S2CID 43726887.
• Blanc V, Kennedy S, Davidson NO (October 2003). "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling". The Journal of Biological Chemistry. 278 (42): 41198–204. doi:10.1074/jbc.M302951200. PMID 12896982.
• Güttinger S, Mühlhäusser P, Koller-Eichhorn R, Brennecke J, Kutay U (March 2004). "Transportin2 functions as importin and mediates nuclear import of HuR". Proceedings of the National Academy of Sciences of the United States of America. 101 (9): 2918–23. Bibcode:2004PNAS..101.2918G. doi:10.1073/pnas.0400342101. PMC 365720. PMID 14981248.
• Rebane A, Aab A, Steitz JA (April 2004). "Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR". RNA. 10 (4): 590–9. doi:10.1261/rna.5224304. PMC 1370549. PMID 15037768.
• Lee BJ, Cansizoglu AE, Süel KE, Louis TH, Zhang Z, Chook YM (August 2006). "Rules for nuclear localization sequence recognition by karyopherin beta 2". Cell. 126 (3): 543–58. doi:10.1016/j.cell.2006.05.049. PMC 3442361. PMID 16901787.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.