TOM1

TOM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ELK, 1WRD, 2N2N
Identifiers
Aliases	TOM1, target of myb1 membrane trafficking protein, IMD85
External IDs	OMIM: 604700 MGI: 1338026 HomoloGene: 88453 GeneCards: TOM1
Gene location (Human)
Chr.	Chromosome 22 (human)
End	35,347,992 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	75,796,749 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; skin of abdomen; ; monocyte; ; stromal cell of endometrium; ; minor salivary glands; ; left adrenal gland; ; right lobe of liver; ; anterior pituitary; ; upper lobe of left lung; ; right lung;
	Top expressed in
	lens; ; muscle tissue; ; skeletal muscle tissue; ; lip; ; yolk sac; ; quadriceps femoris muscle; ; heart; ; testicle; ; esophagus; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	clathrin binding; protein binding;
Cellular component	cytosol; endosome; early endosome; extracellular exosome; intracellular anatomical structure; cytoplasm; membrane; plasma membrane; azurophil granule membrane; specific granule membrane;
Biological process	intracellular protein transport; endocytosis; endosomal transport; protein transport; neutrophil degranulation; transport;
	Sources:Amigo / QuickGO
Orthologs
	10043
	21968
	ENSG00000100284
	ENSMUSG00000042870
	O60784
	O88746
	NM_001135729; NM_001135730; NM_001135732; NM_005488
	NM_001136259; NM_011622
	NP_001129201; NP_001129202; NP_001129204; NP_005479
	NP_001129731; NP_035752
	Wikidata
View/Edit Human	View/Edit Mouse

Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene.^[5]^[6]^[7]

The specific function of this gene has not yet been determined, yet it may involve the translocation of growth factor receptor complexes to the lysosome for degradation. This gene is localized to 22q13.1, with HMOX1 and MCM5 distally and HMG2L1 proximally positioned.^[7]

Interactions[edit]

TOM1 has been shown to interact with TOLLIP^[8] and ZFYVE16.^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100284 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042870 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seroussi E, Kedra D, Kost-Alimova M, Sandberg-Nordqvist AC, Fransson I, Jacobs JF, Fu Y, Pan HQ, Roe BA, Imreh S, Dumanski JP (Aug 1999). "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM". Genomics. 57 (3): 380–8. doi:10.1006/geno.1998.5739. PMID 10329004.
^ Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K (May 2004). "Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes". J Biol Chem. 279 (23): 24435–43. doi:10.1074/jbc.M400059200. PMID 15047686.
^ ^a ^b "Entrez Gene: TOM1 target of myb1 (chicken)".
^ Yamakami, Megumi; Yoshimori Tamotsu; Yokosawa Hideyoshi (Dec 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". J. Biol. Chem. 278 (52): 52865–72. doi:10.1074/jbc.M306740200. ISSN 0021-9258. PMID 14563850.
^ Seet, Li-Fong; Liu Ningsheng; Hanson Brendon J; Hong Wanjin (Feb 2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. ISSN 0021-9258. PMID 14613930.

External links[edit]

TOM1 human gene location in the UCSC Genome Browser.
TOM1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100284 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042870 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10329004-5] Seroussi E, Kedra D, Kost-Alimova M, Sandberg-Nordqvist AC, Fransson I, Jacobs JF, Fu Y, Pan HQ, Roe BA, Imreh S, Dumanski JP (Aug 1999). "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM". Genomics. 57 (3): 380–8. doi:10.1006/geno.1998.5739. PMID 10329004.

[pmid15047686-6] Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K (May 2004). "Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes". J Biol Chem. 279 (23): 24435–43. doi:10.1074/jbc.M400059200. PMID 15047686.

[entrez-7] "Entrez Gene: TOM1 target of myb1 (chicken)".

[pmid14563850-8] Yamakami, Megumi; Yoshimori Tamotsu; Yokosawa Hideyoshi (Dec 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". J. Biol. Chem. 278 (52): 52865–72. doi:10.1074/jbc.M306740200. ISSN 0021-9258. PMID 14563850.

[pmid14613930-9] Seet, Li-Fong; Liu Ningsheng; Hanson Brendon J; Hong Wanjin (Feb 2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. ISSN 0021-9258. PMID 14613930.

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Interactions[edit]

References[edit]

Further reading[edit]

External links[edit]