TRHDE

Thyrotropin releasing hormone degrading enzyme is a protein, specifically a pyroglutamyl-peptidase II enzyme, that in humans is encoded by the TRHDE gene.

Function

This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.

Further reading

• Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, Lev D (January 2011). "Vimentin is a novel AKT1 target mediating motility and invasion". Oncogene. 30 (4): 457–70. doi:10.1038/onc.2010.421. PMC 3010301. PMID 20856200.
• Bödeker H, Keim V, Fiedler F, Dagorn JC, Iovanna JL (1999). "PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha". Molecular Cell Biology Research Communications. 2 (3): 150–4. doi:10.1006/mcbr.1999.0166. PMID 10662590.
• Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB (May 2010). "Chemerin, a novel adipokine in the regulation of angiogenesis". The Journal of Clinical Endocrinology and Metabolism. 95 (5): 2476–85. doi:10.1210/jc.2010-0042. PMC 2869547. PMID 20237162.
• Freudenberg J, Lee HS, Han BG, Shin HD, Kang YM, Sung YK, Shim SC, Choi CB, Lee AT, Gregersen PK, Bae SC (April 2011). "Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci". Arthritis and Rheumatism. 63 (4): 884–93. doi:10.1002/art.30235. PMID 21452313.
• Schomburg L, Turwitt S, Prescher G, Lohmann D, Horsthemke B, Bauer K (October 1999). "Human TRH-degrading ectoenzyme cDNA cloning, functional expression, genomic structure and chromosomal assignment". European Journal of Biochemistry. 265 (1): 415–22. doi:10.1046/j.1432-1327.1999.00753.x. PMID 10491199.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.