Talk:HBTU

I believe that a mechanism on how HBTU couples carboxylic acids and amines to make amides may be helpful for viewers of this page who are interested in organic synthesis. I have found a figure depicting the mechanism in a review by Dunetz et. al.^[1]

My thought is that I cannot show the figure from the journal, but I would rather draw the mechanism myself and insert a caption or a subsection with details explaining the mechanism. --Blangmack20 (talk) 18:23, 6 May 2019 (UTC)[reply]

Mistake in Mechanism[edit]

I think that there is an error in the mechanism after the first transitions state where the nitrogen lone pair should form a double bond to the carbon creating a positive charge — Preceding unsigned comment added by 2A0C:5BC0:40:2E34:82B:841F:4E36:75F9 (talk) 15:31, 19 August 2020 (UTC)[reply]

^ Joshua R. Dunetz*†, Javier Magano*‡, and Gerald A. Weisenburger*‡† Process Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, California 94404, United States ‡ Chemical Research & Development, Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, United States (2016).Organic Process Research and Development. 20 (2), pp 140–177 DOI: 10.1021/op500305s

[1] Joshua R. Dunetz*†, Javier Magano*‡, and Gerald A. Weisenburger*‡† Process Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, California 94404, United States ‡ Chemical Research & Development, Pfizer Worldwide Research & Development, Eastern Point Road, Groton, Connecticut 06340, United States (2016).Organic Process Research and Development. 20 (2), pp 140–177 DOI: 10.1021/op500305s

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