Talk:MIAT (gene)

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As part of a class assignment I intend to edit this page by adding the following sections: role in pathologies (with focus on myocardial infarction, schizophrenia, and cancer), and Structure/Location. Drafts of the edits are available in my sandbox. User:Jkrodg/sandbox Jkrodg (talk)

Peer review and responses during the educational assignment in Fall 2016

The introductory section for the MIAT gene article seems to be generally accessible for non-experts. It begins by explaining the overall structure of the gene, and how its transcript is a functional RNA (long non-coding RNA). The structure of the gene is expanded on by describing its length in terms of bases, as well as its orientation as a plus-sense strand. One piece of critical information that is described in the introductory structure section is the description of the gene as not encoding any translational product. However, one bit of information that could be included within the structure section is a description referring to the single nucleotide polymorphisms that are associated with MIAT, and at what locations they occur.

As for the content of each section, I believe that the Myocardial Infarction subheading could be expanded on. The article "Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction" that is referenced, could have additional details and figures drawn from it in order to supply information regarding the connection between the myocardial infarction associated transcript (MIAT) and myocardial infarction as a pathology. Important terms/concepts do not seem to be linked to their respective Wikipedia pages, but this can easily be corrected during the revision phase of the project. There are many terms used throughout the article which can be linked back for further reference, such as Chromosome 22 (human) and myocardial infarction.

The examples included throughout the article seem to be appropriate considering their inclusion under the heading of “Function in Pathology”. The MIAT gene seems to have implications in various diseases, which are described in detail throughout the article. Although the myocardial infarction pathology could be expanded on, the other two examples (Schizophrenia and Other Pathologies) are appropriately described. The content found in the article does not seem to be duplicative of any other content on Wikipedia. In fact, the myocardial infarction page on Wikipedia has a genetics subheading, which does not list MIAT as a following gene that may have an association with MI. The figure used in the article seems to be original, and allows for the easy visualization of the location of MIAT on Chromosome 22. The references are also complete, with around 20 references used. However, all the references seem to come from a journal source.

In summary, the MIAT gene article does a great job expanding on the current Wikipedia article on MIAT. There seems to be an emphasis on the gene’s function in pathology, and the examples included are relevant. However, additional detail regarding the role of MIAT in myocardial infarctions could be useful, especially considering that the gene is named after MI. The references used throughout the essay seemed to be very focused on the involvement of the gene in pathology, particularly schizophrenia pathology. The figure used is also quite useful in order to visualize the location of the MIAT gene on Chromosome 22.

Manawars95 (talk) 16:49, 19 October 2016 (UTC)

For the Wikipedia page regarding the MIAT gene, the introductory section is accessible for non-experts. The terms are described fairly well so a general reader will be able to grasp a basic understanding of the important details associated with the MIAT gene. In addition, the introduction provides an easy to follow outline that is carried throughout the rest of the Wikipedia page. For any details that are not explained directly, the term is then hyperlinked to the corresponding Wikipedia page that will provide further information on the subject. The appropriate terms are highlighted throughout the text because they redirect readers of all levels toward the necessary pages, ranging from terms found in advanced research articles to general biology and chemistry vocabulary. The content throughout the paper does not duplicate other Wikipedia pages, but the final sentence of the first paragraph in the “Structure” section is redundant from the introductory portion.

The figure used in the Wikipedia page is appropriately located and coincides with the subtopic it falls under. The image clearly demonstrates the location of the MIAT gene on chromosome 22, but the details further explained throughout the “Structure” section of the page could be more clearly understood if accompanied by an image demonstrating the specific genetic structure of the gene, such as the arrangement of the promoter, exons, and introns.

The reference section is complete with five or greater cited sources, and they are properly cited throughout the Wikipedia page to avoid any problems with plagiarism. All of the used references come from journal sources.

Overall, the page is well organized and follows an outline that is easy for presenting the information on the MIAT gene in an increasingly complex manner. This helps the reader develop a stronger knowledge of the topic before delving into more convoluted subject matter. In addition, the general wording used throughout comes across easily for a non-expert to read. Some terms, such as glioblastoma multiforme, should be further elaborated upon so people understand all details related to the disease- part of body, type of illness, etc. These smaller details will help tie together all of the other information discussed throughout the page. Also, the page references studies which give results important to the MIAT gene, but the details of such findings are never actually explained. A brief explanation of the significance of the findings will further elaborate on the topics discussed, benefitting the overall Wikipedia page. An example would be explaining how the analysis of MIAT and OCT4 show other regulatory factors are at play. Aside from these few areas, the page is well written and contains a lot of useful information that improves upon the original page.

Wolverine1721 (talk) 18:02, 19 October 2016 (UTC)

The introductory section did a good job addressing the location and structure of the MIAT gene. It was brief and easy for a reader to understand. The “Myocardial Infarction” section under the “Function in Pathology” heading was also very informative. I enjoyed that it was easily explained. It was long enough to explain the biological significance of the gene, but not too long that the reader got lost. The example included was interesting, but seemed a little scattered. It may be easier for a reader to follow along if this section was organized into paragraphs rather than in sections of 1-2 sentences. The content is not duplicative of any other content that is already on Wikipedia. Even though the introductory section was informative, I think more information could have also been added.

The figure included provides information about the location of the MIAT gene on chromosome 22. This is interesting to include because it allows the reader to visualize the gene and how it is located on the chromosomes that make up our genetic material. The figure is an original, as stated by viewing the details of the picture, and it is of high quality. It is simple and easy to understand. There are 18 sources included at the moment, well over the required number of sources for this assignment. All of the listed sources are from journal sources.

Group 3’s Wikipedia page focuses on the myocardial infarction associated transcript gene or MIAT gene. This page has used many sources from various journals of medicine and research journals to explain the possibility that knowledge of the genetic factors that contribute to the pathogenesis of myocardial infarction can lead to better diagnosis, prevention, and treatment. The group did a great job explaining the schizophrenia example and how it is linked to the MIAT gene. I think some of the genes introduced within this example could be broken down further to make sense to a reader who may not have experience in this area. The group also did a great job including the presence of other pathologies that are connected to the MIAT gene.

Sahithia (talk) 21:54, 19 October 2016 (UTC)

The introductory section adequately describes the structure and location of the MIAT gene. It uses language that is easily accessible to the general public, and does a good job of describing the basics of MIAT, such as the orientation and function as a functional RNA. One suggestion for the introduction would be to include the information about alternative splicing found under the heading “Schizophrenia” since that adds valuable insight into the layout of the gene. Overall, the information found under each heading was strong and generally concise. All the sections did a good job of explaining the underlying pathology behind the specific disease, and how it relates to MIAT. Although the important terms are not linked to their Wikipedia pages, all the information is original and is not redundant.

The figure does a good job of mapping out the location of Chromosome 22. The picture is very clear and easy to understand. One addition to the picture could include other genes located close to MIAT on the chromosome. It is possible that other genes could affect the expression of MIAT, and it would be interesting to note which genes reside in close proximity.

The group did an exceptional job using sources, as there are 20 cited sources, all of which came from published journal articles. They are linked at the appropriate locations in the text as well.

The page overall is very organized and easy to follow. There is a good introduction of the gene under the “Structure” heading, which allows the reader to familiarize themselves with the structure and general function of the gene. Afterwards, there is a good description of the different pathologies associated with abnormal expression levels of MIAT. The figure gives a good geographical mapping of the gene within the context of Chromosome 22. In the text itself, I think that certain terms could be explained more in-depth. For example, someone may not understand what myocardial infarction is, and it may be beneficial to have a quick description of the condition. Another suggestion would be to refer to Gomafu as MIAT under the “Schizophrenia” heading in order to be consistent so the reader can easily follow the language. In addition, it may be helpful to flesh our some of the descriptions a little more. For example, under the “Other Pathologies” section, it is mentioned that glioma cells have down-regulated MIAT. Mentioning why this would lead to the progression of cancer would provide more enriching information for the reader. However, the page overall is very concise and informative.

Wolverine1738 (talk) 03:55, 20 October 2016 (UTC)

Additional comments from the librarians

A few things to be careful when making your edits to the main article. First, make sure you don't lose the gene sidebar that's currently present. Second, you probably want to have a brief summary prior to the table of contents - you may have been planning to use the current stub contents as the summary, which is what I'd recommend. You'll also want to make sure that your table of contents is structured properly: the title of the article shouldn't be the top-level entry; "Structure" and "Function in pathology" should be "1" and "2" rather than "1.1" and "1.2" (likewise, the "Function in pathology" sub-bullets should move up one level); and the References section should get its own heading in the ToC. Finally, I recommend being more aggressive in linking technical terms in the article to their own Wikipedia pages. ScottMLibrary (talk) 21:08, 20 October 2016 (UTC)