Tamanthi Wildlife Reserve is a wildlife reserve of Burma (Myanmar). It was established on April 11, 1974 on the eastern bank of the Chindwin River, across from the town of Tamanthi. It lies within the Hkamti District of Sagaing Region, and covers 830.40 sq mi (2,150.7 km2), bounded between the Uyu and Chindwin rivers with 230.40 sq mi (596.7 km2) of the area in Homalin Township, and 600 sq mi (1,600 km2) in Hkamti Township.
The sanctuary is home to tigers, elephants, gaur (Asiatic bison), leopards, serow, and bear. In all over 30 mammals are found there. Formerly it was the home of the Sumatran Rhinoceros (Didermocherus Sumatrensis) and the Javan Rhinoceros (Rhinoceros sondaicus), which seem to have become extinct in the area in the 1980s. In the past, it was a favourite ground for wild life hunters and poachers, because its remoteness had preserved a high biodiversity. Folklore has the area as a home for were-tigers, who appear to hunters as beautiful young girls in the day time, only to become ravening beasts at night. Among the many birds found in the reserve are the white-winged wood duck (Cairina scutulata) and the masked finfoot (Heliopais personata). Of note among the amphibians is an endangered species of roofed turtle which are found there.