UBE1L

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Ubiquitin-like modifier activating enzyme 7
Identifiers
Symbols UBA7 ; D8; UBA1B; UBE1L; UBE2
External IDs OMIM191325 MGI1349462 HomoloGene2502 GeneCards: UBA7 Gene
RNA expression pattern
PBB GE UBE1L 1294 at tn.png
PBB GE UBE1L 203281 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7318 74153
Ensembl ENSG00000182179 ENSMUSG00000032596
UniProt P41226 E9Q2Z8
RefSeq (mRNA) NM_003335 NM_023738
RefSeq (protein) NP_003326 NP_076227
Location (UCSC) Chr 3:
49.84 – 49.85 Mb
Chr 9:
107.98 – 107.98 Mb
PubMed search [1] [2]

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia.[2]

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