UTY (gene)

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Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UTY ; UTY1
External IDs OMIM400009 HomoloGene56022 GeneCards: UTY Gene
RNA expression pattern
PBB GE UTY 208067 x at tn.png
PBB GE UTY 211149 at tn.png
PBB GE UTY 210322 x at tn.png
More reference expression data
Species Human Mouse
Entrez 7404 n/a
Ensembl ENSG00000183878 n/a
UniProt O14607 n/a
RefSeq (mRNA) NM_001258249 n/a
RefSeq (protein) NP_001245178 n/a
Location (UCSC) Chr Y:
15.36 – 15.59 Mb
PubMed search [1] n/a

Histone demethylase UTY is an enzyme that in humans is encoded by the UTY gene.[1][2][3]

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. This protein is a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]


UTY (gene) has been shown to interact with TLE1.[4]


  1. ^ Greenfield A, Scott D, Pennisi D, Ehrmann I, Ellis P, Cooper L, Simpson E, Koopman P (Jan 1997). "An H-YDb epitope is encoded by a novel mouse Y chromosome gene". Nat Genet 14 (4): 474–478. doi:10.1038/ng1296-474. PMID 8944031. 
  2. ^ Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, Koopman P (May 1998). "The UTX gene escapes X inactivation in mice and humans". Hum Mol Genet 7 (4): 737–742. doi:10.1093/hmg/7.4.737. PMID 9499428. 
  3. ^ a b "Entrez Gene: UTY ubiquitously transcribed tetratricopeptide repeat gene, Y-linked". 
  4. ^ Grbavec, D; Lo R; Liu Y; Greenfield A; Stifani S (Jan 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". Biochem. J. (ENGLAND) 337 (1): 13–7. doi:10.1042/0264-6021:3370013. ISSN 0264-6021. PMC 1219929. PMID 9854018. 

Further reading[edit]