User:Afwilson4030/Rev-ErbA
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(Note not meant for actual page: we want to change the title of this page to Rev-Erb Proteins, furthermore, conversion to a stub was deliberate)
| nuclear receptor subfamily 1, group D, member 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | NR1D1 | ||||||
| Alt. symbols | ear-1, hRev, Rev-ErbAalpha, THRA1 | ||||||
| NCBI gene | 9572 | ||||||
| HGNC | 7962 | ||||||
| OMIM | 602408 | ||||||
| RefSeq | NM_021724 | ||||||
| UniProt | P20393 | ||||||
| Other data | |||||||
| Locus | Chr. 17 q11.2 | ||||||
| |||||||
| nuclear receptor subfamily 1, group D, member 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | NR1D2 | ||||||
| Alt. symbols | BD73, RVR, EAR-1r, HZF2, Hs.37288 | ||||||
| NCBI gene | 9975 | ||||||
| HGNC | 7963 | ||||||
| OMIM | 602304 | ||||||
| RefSeq | XM_001130839 | ||||||
| UniProt | Q14995 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p24.1 | ||||||
| |||||||
The Rev-Erb proteins are members of the nuclear receptor (NR) superfamily of intracellular transcription factors and key regulatory components of the circadian clock. There are two forms of the receptor, Rev-Erb alpha and Rev-Erb beta, which are each encoded by a separate gene (NR1D1 and NR1D2, respectively).[1][2]
These proteins act as key regulators of clock gene expression through transcriptional repression of Bmal1. Through their regulation of clock-controlled genes, the Rev-Erb proteins affect several physiological processes throughout the body, including metabolic, endocrine, and immune pathways.[3][4][5]
See Also[edit]
References[edit]
- ^ Lazar, Mitchell A.; Jones, Karen E.; Chin, William W. (1990-03-01). "Isolation of a cDNA Encoding Human Rev-ErbAα: Transcription from the Noncoding DNA Strand of a Thyroid Hormone Receptor Gene Results in a Related Protein That Does Not Bind Thyroid Hormone". DNA and Cell Biology. 9 (2): 77–83. doi:10.1089/dna.1990.9.77. ISSN 1044-5498.
- ^ Dumas, B; Harding, H P; Choi, H S; Lehmann, K A; Chung, M; Lazar, M A; Moore, D D (1994-08-01). "A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb". Molecular Endocrinology. 8 (8): 996–1005. doi:10.1210/mend.8.8.7997240. ISSN 0888-8809.
- ^ Scheiermann, Christoph; Kunisaki, Yuya; Frenette, Paul S. (2013-02-08). "Circadian control of the immune system". Nature Reviews Immunology. 13 (3): 190–198. doi:10.1038/nri3386. ISSN 1474-1733. PMC 4090048. PMID 23391992.
{{cite journal}}: CS1 maint: PMC format (link) - ^ Duez, Hélène; Staels, Bart (2009-08-20). "Rev-erb-α: an integrator of circadian rhythms and metabolism". Journal of Applied Physiology. 107 (6): 1972–1980. doi:10.1152/japplphysiol.00570.2009. ISSN 8750-7587. PMC 2966474. PMID 19696364.
{{cite journal}}: CS1 maint: PMC format (link) - ^ Wang, Shuai; Li, Feng; Lin, Yanke; Wu, Baojian (2020). "Targeting REV-ERBα for therapeutic purposes: promises and challenges". Theranostics. 10 (9): 4168–4182. doi:10.7150/thno.43834. ISSN 1838-7640. PMC 7086371. PMID 32226546.
{{cite journal}}: CS1 maint: PMC format (link)