User:Gshan12/Neuroepithelial Cells Proposal

Wikipedia Proposal: Neuroepithelial Cells

Spencer Heggers, Leo Magrini, Gururaj Shan

General definition:

Neuroepithelial Cells are progenitor cells in the Nervous System, deriving from stem cells in several different stages of development. They appear during embryonic development of the neural tube as well as in adult neurogenesis in specific areas of the Central Nervous System. These cells have also been called "neuroblasts" in an effort to delineate them as precursors to neurons and glial cells.

Main points

Embryonic Neural Development

• Formation of the neural plate and neural tube
• Development of apical-basal polarity

Adult Neurogenesis

• Genesis of Neuroepithelial Cells in the Subventricular Zone and the Hippocampus
• Purpose of descendant neurons and radial glial cells.

Associated Diseases

• Depression
• Cysts
• Tumors

References

1. Magdalena Götz & Wieland B. Huttner. (October 2005). The Cell Biology of Neurogenesis. Nature Reviews Molecular Cell Biology 6, 777-788 | doi:10.1038/nrm1739. [1]
2. Zolessi, F. R. (2009). Vertebrate Neurogenesis: Cell Polarity. eLS | doi: 10.1002/9780470015902.a0000826.pub2. [2].
3. Jacobs, B.L., Praag H., Gage F. H. (May 2000). Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry 5(3):262-269. [3]
4. Wulf Haubensak, Alessio Attardo, Winfried Denk, and Wieland B. Huttner. (2004). Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: A major site of neurogenesis. PNAS, vol. 101 no. 9 3196-3201 | doi: 10.1073/pnas.0308600100. [4]
5. Ann McDonald. (2007). Prenatal Development — The Dana Guide. The Dana Foundation. [5]

Division of workload:

We will work collectively on each section by meeting at regularly scheduled times to edit one section of our article in order to collaboratively construct the Wikipedia page.