User:Jock Boy/Classroom/The Nice Hollaback Girl

This page is to keep track of The Nice Hollaback Girl's progress within Jock Boy's adoption program

Lessons[edit]

Lessons	Required/Optional	Grade	Done?
Starters	Required	A-	Well done!
General Wikimarkup	Required
Citations	Required
Article Repair 101	Required
Templates	Strongly Recommended
Infoboxes	Optional
User Permissions	Optional
Reviewing articles	Optional
Advanced Templates	Optional
Vandalism: Part 1	Required
Vandalism: Part 2	Recommended
Organizing Articles	Optional

Types of requirement[edit]

{Adoptees, ignore this...)

|bgcolor=19abff|Required
|bgcolor=3dc63d|Optional
|bgcolor=dce734|Recommended

Lesson 1: Starters - Answer[edit]

This lesson has been completed as: PASSED, with grades and comments. Grade: A-

Jock Boy/Classroom/The Nice Hollaback Girl
Clinical data

Pregnancy category	C
Routes of administration	Oral, Transdermal, IV, Nasal
ATC code	N06BA04 (WHO)
Legal status
Legal status	AU: S8 (Controlled drug) CA: Schedule III UK: Class B US: Schedule II
Pharmacokinetic data
Bioavailability	11–52%
Protein binding	30%
Metabolism	Liver
Elimination half-life	2–4 hours
Excretion	Urine
Identifiers
IUPAC name methyl 2-phenyl-2-(piperidin-2-yl)acetate
CAS Number	113-45-1
PubChem CID	4158
DrugBank	APRD00657
ChemSpider	4015
Chemical and physical data
Formula	C₁₄H₁₉NO₂
Molar mass	233.31 g/mol g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COC(=O)C(C1CCCCN1)c1ccccc1

Indicated for:

Migraines

Other uses:

Methylphenidorgil (more commonly reffered to as Gapratron) is a prescription Analgesic and one of the primary drugs used to treat acute cephalalgia (Migraine). While usually taken in pill form it can be administered through a transdermal patch.

History[edit]

Methylphenidorgil was discovered in 1968 by Swiss pyshicist Dr. Kim Von Wolfgang as a posible cure to dementia however by the late 70's it was being prescribed as a treatment for acute migraines and in 1981 its patent was bought by Pfizer Incorporated however in 1983 Methylphenidorgil was banned when a link between it and miscarriages was discovered. (see below)

Controversy[edit]

In 1982 the French Mary Anne Frank a migraine sufferer sued Pfizer for 10 million American dollars saying the drug Methylphenidorgil had caused her miscarriage, a inquiry was launched and it was found that Methylphenidorgil caused the body to produce myelin, a hormone that cut of oxygen flow to the foetus. Ms. Frank was paid the sum of 10 million dollars for pschological damage and Methylphenidorgil was subsequently banned in 1982. Another though much less publicised case of controversy was when it was dicovered that researchers had use live animals as test subjects which provoked the outrage of many animal rights organisations including PETA.

Pharmacology[edit]

Methylphenidate has binding affinity for both the dopamine transporter and norepinephrine transporter, with the Dextromethylphenidate enantiomers displaying a prominent affinity for the norepinephrine transporter. Both the dextro- and levorotary enantiomers displayed receptor affinity for the serotonergic 5HT1A and 5HT2B subtypes, though direct binding to the serotonin transporter was not observed.

Comments[edit]

You did a great job. Even though this was not a real drug, you could have fooled me. It is clear you spent time reading over articles to determine proper writing style and formatting. You passed with flying colors, and this is a very high A- grade. Good job! Jock Boy (t/c) Sign 21:01, 30 November 2008 (UTC)