User:Mr. Ibrahem/Acarbose

Mr. Ibrahem/Acarbose
Clinical data
Trade names	Glucobay, Precose, Prandase, others
Other names	(2R,3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5- {[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl- 5-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3- (hydroxymethyl)cyclohex-2-en-1-yl]amino} tetrahydro-2H-pyran-2-yl]oxy}-3,4-dihydroxy- 6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}- 6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4-triol
AHFS/Drugs.com	Monograph
MedlinePlus	a696015
License data	US DailyMed: Acarbose; US FDA: Precose;
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth (tablets)
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	Extremely low
Metabolism	Gastrointestinal tract
Elimination half-life	2 hours
Excretion	Kidney (less than 2%)
Identifiers
	IUPAC name O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-D-glucopyranose;
Chemical and physical data
Formula	C25H43NO18
Molar mass	645.608 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O([C@H]1[C@H](O)[C@@H](O)[C@H](O)O[C@@H]1CO)[C@H]4O[C@@H]([C@@H](O[C@H]3O[C@H](C)[C@@H](N[C@H]2/C=C(/CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]3O)[C@H](O)[C@H]4O)CO;
	InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1 ; Key:XUFXOAAUWZOOIT-SXARVLRPSA-N ;
	(verify)

Acarbose is a medication used to treat type 2 diabetes, along with diet and exercise.^[1] It may be used in those who cannot take metformin or in addition to other diabetes medications.^[1] Its benefit is small.^[2] It is taken by mouth with each meal.^[1] Maximal effect may take 2 weeks.^[1]

Common side effects include abdominal pain, diarrhea, and increase bowel gas.^[1] When used alone, it does not typically result in low blood sugar.^[1] Other side effects include increased liver enzymes.^[1] Use is not recommended in those at risk of bowel obstruction.^[2] It works by slowing down the digestion of carbohydrates.^[1]

Acarbose was approved for medical use in the United States in 1995.^[1] It is available as a generic medication.^[3] In the United States a month costs about 16 USD as of 2021.^[3] In the United Kingdom this amount costs the NHS about 15 pounds.^[2]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Acarbose Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2020. Retrieved 18 July 2021.
^ ^a ^b ^c BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 729. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ ^a ^b "Acarbose Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 23 October 2016. Retrieved 18 July 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Acarbose Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2020. Retrieved 18 July 2021.

[BNF80-2] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 729. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[GX2021-3] "Acarbose Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 23 October 2016. Retrieved 18 July 2021.

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