User:Mr. Ibrahem/Bromocriptine
Clinical data | |
---|---|
Trade names | Parlodel, Cycloset, others[1] |
Other names | Bromocriptine mesilate, bromocriptine mesylate, 2-Bromoergocriptine; CB-154 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682079 |
Pregnancy category |
|
Routes of administration | By mouth |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 28% of oral dose |
Metabolism | Extensively liver-mediated |
Elimination half-life | 12–14 hours |
Excretion | 85% bile (feces), 2.5–5.5% urine |
Identifiers | |
| |
Chemical and physical data | |
Formula | C32H40BrN5O5 |
Molar mass | 654.606 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Bromocriptine, sold under the brand name Parlodel among others, is a medication used to treat prolactinomas, Parkinson's disease, acromegaly, neuroleptic malignant syndrome, and stop milk production.[2][3] It may also be used in type 2 diabetes.[4] It is taken by mouth.[2]
Common side effects include nausea, headache, tiredness, dizziness, constipation, and sleepiness.[3] Other side effects may include low blood pressure, and pericardial effusions, confusion.[3] It has been used by many pregnant women without any evidence of harm to the baby.[5] It works by activating dopamine receptors and decreasing the release of prolactin.[2]
Bromocriptine was patented in 1968 and approved for medical use in 1975.[6] It is available as a generic medication.[2] In the United Kingdom 30 pills of 2.5 mg cost the NHS about £75 as of 2021.[2] In the United States this amount costs about 30 USD.[7]
References[edit]
- ^ "Bromocriptine international brand names". Drugs.com. Archived from the original on 6 August 2017. Retrieved 13 July 2017.
- ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 441. ISBN 978-0857114105.
- ^ a b c d e "Bromocriptine Monograph for Professionals". Drugs.com. Archived from the original on 24 January 2021. Retrieved 12 January 2022.
- ^ a b "DailyMed - CYCLOSET- bromocriptine mesylate tablet". dailymed.nlm.nih.gov. Archived from the original on 29 March 2021. Retrieved 12 January 2022.
- ^ "Bromocriptine Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 12 January 2022.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 533. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-06-30.
- ^ "Bromocriptine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 7 November 2016. Retrieved 12 January 2022.