User:Mr. Ibrahem/Ketoprofen

Mr. Ibrahem/Ketoprofen
Clinical data
Trade names	Oruvail, others
AHFS/Drugs.com	Monograph
MedlinePlus	a686014
License data	US DailyMed: Ketoprofen;
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth, topical, intravenous (veterinary use)
Drug class	NSAID
Legal status
Legal status	AU: S3 (Pharmacist only) / S4; US: ℞-only; Rx-only & OTC;
Pharmacokinetic data
Protein binding	99%
Elimination half-life	2–2.5 hours
Identifiers
	IUPAC name (RS)-2-(3-benzoylphenyl)propanoic acid;
Chemical and physical data
Formula	C16H14O3
Molar mass	254.285 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES CC(c1cccc(c1)C(=O)c2ccccc2)C(=O)O;
	InChI InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19) ; Key:DKYWVDODHFEZIM-UHFFFAOYSA-N ;
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Ketoprofen is a nonsteroidal anti-inflammatory drugs (NSAID) used to treat pain and inflammation including painful periods.^[1] It may be taken by mouth or applied to the skin.^[2]

Common side effects, when taken by mouth, include stomach pain and nausea.^[2] Other side effects may include gastrointestinal bleeding, heart attacks, high blood pressure, heart failure, kidney problems, and anaphylaxis.^[1] Use in the later part of pregnancy may harm the baby.^[1] It is in the propionic acid class and works by blocking COX1 and COX2.^[1]

Ketoprofen was patented in 1967 and approved for medical use in 1980.^[3] It is available as a generic medication and over the counter.^[1]^[2] In the United Kingdom 28 tablets of 200 mg costs the NHS about £24 as of 2021.^[2] This amount in the United States costs about 38 USD.^[4]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g "Ketoprofen Monograph for Professionals". Drugs.com. Archived from the original on 8 September 2021. Retrieved 1 December 2021.
^ ^a ^b ^c ^d ^e BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1191. ISBN 978-0857114105.
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 520. ISBN 9783527607495. Archived from the original on 2020-08-06. Retrieved 2020-10-17.
^ "Ketoprofen Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 1 December 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g "Ketoprofen Monograph for Professionals". Drugs.com. Archived from the original on 8 September 2021. Retrieved 1 December 2021.

[BNF81-2] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1191. ISBN 978-0857114105.

[Fis2006-3] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 520. ISBN 9783527607495. Archived from the original on 2020-08-06. Retrieved 2020-10-17.

[4] "Ketoprofen Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 1 December 2021.

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