User:Mr. Ibrahem/Ursodeoxycholic acid

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Mr. Ibrahem/Ursodeoxycholic acid
Clinical data
Trade namesActigall, Urso, others
Other namesUrsodiol
AHFS/Drugs.comMonograph
MedlinePlusa699047
License data
Pregnancy
category
Routes of
administration		By mouth[2]
Legal status
Legal status
Identifiers
  • 3α,7β-dihydroxy-5β-cholan-24-oic acid
    OR
    (R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-
    10,13-dimethylhexadecahydro-
    1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
Chemical and physical data
FormulaC24H40O4
Molar mass392.56 g·mol−1
3D model (JSmol)
Melting point203 °C (397 °F)
  • O=C(O)CC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]4[C@H]2[C@@H](O)C[C@@H]3C[C@H](O)CC[C@@]34C)C
  • InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1 checkY
  • Key:RUDATBOHQWOJDD-UZVSRGJWSA-N checkY
  (verify)

Ursodeoxycholic acid (UDCA), also known as ursodiol, is a naturally occurring bile acid, used for several conditions of the liver and bile ducts.[4] This includes treatment of primary biliary cirrhosis and to prevent or breakdown gallstones.[4] It is taken by mouth.[2]

Common side effects include diarrhea and pale stool.[2] Other side effects may include abdominal pain, vomiting, and a rash.[2] Following use in a small number of pregnancies, it appears to be relatively safe.[5] Ursodeoxycholic acid normally occurs in people in small amounts.[4] It is believed to work in part by blocking the release and uptake of cholesterol.[4]

Ursodeoxycholic acid was approved for medical use in the United States in 1987.[4] It was first clearly identified in bear bile in 1927, though had been used for centuries in traditional Chinese medicine.[6][7] It is available as a generic medication.[4] In the United Kingdom 100 tablets of 500 mg costs the NHS about £50 as of 2021 while this amount in the United States costs about 180 USD.[2][8]

References[edit]

  1. ^ a b "Ursodiol Use During Pregnancy". Drugs.com. 4 November 2019. Archived from the original on 20 February 2020. Retrieved 20 February 2020.
  2. ^ a b c d e f g BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 96. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
  3. ^ "Ursodeoxycholic acid 300mg Tablets - Summary of Product Characteristics (SmPC)". (emc). 10 July 2019. Archived from the original on 13 August 2020. Retrieved 29 April 2020.
  4. ^ a b c d e f g "Ursodiol Monograph for Professionals". Drugs.com. Archived from the original on 7 May 2021. Retrieved 13 September 2021.
  5. ^ "Ursodiol Use During Pregnancy". Drugs.com. Archived from the original on 20 February 2020. Retrieved 13 September 2021.
  6. ^ Sneader, Walter (23 June 2005). Drug Discovery: A History. John Wiley & Sons. p. 273. ISBN 978-0-471-89979-2. Archived from the original on 22 September 2021. Retrieved 13 September 2021.
  7. ^ Chivian, Eric; Bernstein, Aaron (2 June 2008). Sustaining Life: How Human Health Depends on Biodiversity. Oxford University Press. p. 227. ISBN 978-0-19-972120-7. Archived from the original on 22 September 2021. Retrieved 13 September 2021.
  8. ^ "Ursodiol Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 16 January 2021. Retrieved 13 September 2021.
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