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Valyl-tRNA synthetase
Symbols VARS ; G7A; VARS1; VARS2
External IDs OMIM192150 MGI90675 HomoloGene4587 ChEMBL: 2612 GeneCards: VARS Gene
EC number
RNA expression pattern
PBB GE VARS 201797 s at tn.png
PBB GE VARS 201796 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7407 22321
Ensembl ENSG00000096171 ENSMUSG00000007029
UniProt P26640 Q9Z1Q9
RefSeq (mRNA) NM_006295 NM_011690
RefSeq (protein) NP_006286 NP_035820
Location (UCSC) Chr 6:
31.75 – 31.76 Mb
Chr 17:
35 – 35.02 Mb
PubMed search [1] [2]

Valyl-tRNA synthetase is an enzyme that in humans is encoded by the VARS gene.[1][2]

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.[2]

See also[edit]


  1. ^ Bonnefond L, Fender A, Rudinger-Thirion J, Giege R, Florentz C, Sissler M (Mar 2005). "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS". Biochemistry 44 (12): 4805–16. doi:10.1021/bi047527z. PMID 15779907. 
  2. ^ a b "Entrez Gene: VARS valyl-tRNA synthetase". 

Further reading[edit]