WAC (gene)

WAC
Identifiers
Aliases	WAC, BM-016, PRO1741, Wwp4, DESSH, WW domain containing adaptor with coiled-coil
External IDs	OMIM: 615049 MGI: 2387357 HomoloGene: 41148 GeneCards: WAC
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.1|10p12.1-p11.2 Start 28,532,493 bp End 28,623,112 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 A1 Start 7,868,832 bp End 7,929,028 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell secondary oocyte Brodmann area 23 germinal epithelium caput epididymis corpus epididymis parietal pleura superficial temporal artery amniotic fluid Achilles tendon Top expressed in ventromedial nucleus body of femur ciliary body medullary collecting duct mammillary body seminal vesicula ganglionic eminence retinal pigment epithelium maxillary prominence substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II complex binding chromatin binding protein binding Cellular component nuclear speck spliceosomal complex nucleus nucleoplasm Biological process positive regulation of transcription, DNA-templated histone monoubiquitination positive regulation of macroautophagy regulation of transcription, DNA-templated histone H2B conserved C-terminal lysine ubiquitination transcription, DNA-templated cellular response to DNA damage stimulus negative regulation of proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51322 225131 Ensembl ENSG00000095787 ENSMUSG00000024283 UniProt Q9BTA9 Q924H7 RefSeq (mRNA) NM_016628 NM_100264 NM_100486 NM_001146298 NM_001282093 NM_153085 NM_001360956 RefSeq (protein) NP_057712 NP_567822 NP_567823 NP_001139770 NP_001269022 NP_694725 NP_001347885 Location (UCSC) Chr 10: 28.53 – 28.62 Mb Chr 18: 7.87 – 7.93 Mb PubMed search
Wikidata
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WW domain-containing adapter protein with coiled-coil is a protein that in humans is encoded by the WAC gene.

The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known.

Further reading

• Sudol M, Sliwa K, Russo T (2001). "Functions of WW domains in the nucleus". FEBS Lett. 490 (3): 190–5. doi:10.1016/S0014-5793(01)02122-6. PMID 11223034. S2CID 20463526.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.