WARS2
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| Tryptophanyl tRNA synthetase 2, mitochondrial | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | WARS2; TrpRS | ||||||||||||
| External IDs | OMIM: 604733 MGI: 1917810 HomoloGene: 5673 GeneCards: WARS2 Gene | ||||||||||||
| EC number | 6.1.1.2 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10352 | 70560 | |||||||||||
| Ensembl | ENSG00000116874 | ENSMUSG00000004233 | |||||||||||
| UniProt | Q9UGM6 | Q8BFV8 | |||||||||||
| RefSeq (mRNA) | NM_015836.3 | NM_027462.4 | |||||||||||
| RefSeq (protein) | NP_056651.1 | NP_081738.2 | |||||||||||
| Location (UCSC) | Chr 1: 119.57 – 119.68 Mb |
Chr 3: 98.94 – 99.04 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Tryptophanyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the WARS2 gene.[1][2][3]
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.[3]
[edit] References
- ^ Martinez-Dominguez MT, Justesen J, Kruse TA, Hansen LL (Mar 1999). "Assignment of the human mitochondrial tryptophanyl-tRNA synthetase (WARS2) to 1p13.3→p13.1 by radiation hybrid mapping". Cytogenet Cell Genet 83 (3–4): 249–50. doi:10.1159/000015196. PMID 10072595.
- ^ Jorgensen R, Sogaard TM, Rossing AB, Martensen PM, Justesen J (Jul 2000). "Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase". J Biol Chem 275 (22): 16820–6. doi:10.1074/jbc.275.22.16820. PMID 10828066.
- ^ a b "Entrez Gene: WARS2 tryptophanyl tRNA synthetase 2, mitochondrial". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10352.
[edit] Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Liu J, Shue E, Ewalt KL, Schimmel P (2004). "A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase". Nucleic Acids Res. 32 (2): 719–27. doi:10.1093/nar/gkh240. PMC 373357. PMID 14757836. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=373357.
- Gerhard DS, Wagner L, Feingold EA, (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Oh JH, Yang JO, Hahn Y, (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- Gregory SG, Barlow KF, McLay KE, (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Guo LT, Chen XL, Zhao BT, (2007). "Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311". Nucleic Acids Res. 35 (17): 5934–43. doi:10.1093/nar/gkm633. PMC 2034488. PMID 17726052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2034488.
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