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WNT inhibitory factor 1
Protein WIF1 PDB 2d3j.png
Rendering of WIF domain of WIF-1 based on the NMR structure PDB ID 2D3J.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols WIF1 ; WIF-1
External IDs OMIM605186 MGI1344332 HomoloGene31430 GeneCards: WIF1 Gene
RNA expression pattern
PBB GE WIF1 204712 at tn.png
More reference expression data
Species Human Mouse
Entrez 11197 24117
Ensembl ENSG00000156076 ENSMUSG00000020218
UniProt Q9Y5W5 Q9WUA1
RefSeq (mRNA) NM_007191 NM_011915
RefSeq (protein) NP_009122 NP_036045
Location (UCSC) Chr 12:
65.44 – 65.52 Mb
Chr 10:
121.03 – 121.1 Mb
PubMed search [1] [2]

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene.[1] WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.[2][3][4]


WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.[1]


  1. ^ a b "Entrez Gene: WIF1 WNT inhibitory factor 1". 
  2. ^ Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY (July 2011). "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1". Nature Structural & Molecular Biology 18 (8): 886–893. doi:10.1038/nsmb.2081. PMC 3430870. PMID 21743455. 
  3. ^ Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids 43 (3): 227–30. doi:10.1007/s11745-007-3144-3. PMID 18256869. 
  4. ^ Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J (Apr 1999). "A new secreted protein that binds to Wnt proteins and inhibits their activities". Nature 398 (6726): 431–6. doi:10.1038/18899. PMID 10201374. 

Further reading[edit]