WIF1

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WNT inhibitory factor 1
Protein WIF1 PDB 2d3j.png
Rendering of WIF domain of WIF-1 based on the NMR structure PDB ID 2D3J.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols WIF1 ; WIF-1
External IDs OMIM605186 MGI1344332 HomoloGene31430 GeneCards: WIF1 Gene
RNA expression pattern
PBB GE WIF1 204712 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11197 24117
Ensembl ENSG00000156076 ENSMUSG00000020218
UniProt Q9Y5W5 Q9WUA1
RefSeq (mRNA) NM_007191 NM_011915
RefSeq (protein) NP_009122 NP_036045
Location (UCSC) Chr 12:
65.44 – 65.52 Mb
Chr 10:
121.03 – 121.1 Mb
PubMed search [1] [2]

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene.[1] WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.[2][3][4]

Function[edit]

WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.[1]

References[edit]

  1. ^ a b "Entrez Gene: WIF1 WNT inhibitory factor 1". 
  2. ^ Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY (July 2011). "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1". Nature Structural & Molecular Biology 18 (8): 886–893. doi:10.1038/nsmb.2081. PMC 3430870. PMID 21743455. 
  3. ^ Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids 43 (3): 227–30. doi:10.1007/s11745-007-3144-3. PMID 18256869. 
  4. ^ Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J (Apr 1999). "A new secreted protein that binds to Wnt proteins and inhibits their activities". Nature 398 (6726): 431–6. doi:10.1038/18899. PMID 10201374. 

Further reading[edit]