XAF1

XAF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LXW
Identifiers
Aliases	XAF1, BIRC4BP, HSXIAPAF1, XIAPAF1, XIAP associated factor 1
External IDs	OMIM: 606717; MGI: 3772572; HomoloGene: 49488; GeneCards: XAF1; OMA:XAF1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	6,775,647 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	72,204,559 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right ovary; ; left ovary; ; gallbladder; ; right uterine tube; ; monocyte; ; right lobe of liver; ; visceral pleura; ; spleen; ; endothelial cell;
	Top expressed in
	decidua; ; cervix; ; right lung; ; epithelium of small intestine; ; right lung lobe; ; subcutaneous adipose tissue; ; carotid body; ; gastrula; ; sciatic nerve; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; zinc ion binding;
Cellular component	cytosol; cytoplasm; nucleus; mitochondrion;
Biological process	apoptotic process; type I interferon signaling pathway; response to interferon-beta;
	Sources:Amigo / QuickGO
Orthologs
	54739
	327959
	ENSG00000132530
	ENSMUSG00000040483
	Q6GPH4
	Q5NBU8
NM_017523; NM_199139; NM_001353134; NM_001353135; NM_001353136;
	NM_001353137; NM_001353138; NM_001353139; NM_001353140
	NM_001037713; NM_001291153
NP_059993; NP_954590; NP_001340063; NP_001340064; NP_001340065;
	NP_001340066; NP_001340067; NP_001340068; NP_001340069
	NP_001032802; NP_001278082
	Wikidata
View/Edit Human	View/Edit Mouse

XIAP-associated factor 1 is a protein that in humans is encoded by the XAF1 gene.^[5]^[6]^[7]

Function

X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001).[supplied by OMIM]^[7]

Interactions

XAF1 has been shown to interact with XIAP.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132530 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040483 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Leaman DW, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S, Borden EC (Aug 2002). "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis". J. Biol. Chem. 277 (32): 28504–11. doi:10.1074/jbc.M204851200. PMID 12029096.
^ ^a ^b Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, Conte D, Tamai K, Craig CG, McBurney MW, Korneluk RG (Feb 2001). "Identification of XAF1 as an antagonist of XIAP anti-Caspase activity". Nat. Cell Biol. 3 (2): 128–33. doi:10.1038/35055027. PMID 11175744. S2CID 19731886.
^ ^a ^b "Entrez Gene: XAF1 XIAP associated factor-1".

Fong WG, Liston P, Rajcan-Separovic E, St Jean M, Craig C, Korneluk RG (2000). "Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines". Genomics. 70 (1): 113–22. doi:10.1006/geno.2000.6364. PMID 11087668.
Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
Byun DS, Cho K, Ryu BK, Lee MG, Kang MJ, Kim HR, Chi SG (2003). "Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas". Cancer Res. 63 (21): 7068–75. PMID 14612497.
Ng KC, Campos EI, Martinka M, Li G (2004). "XAF1 expression is significantly reduced in human melanoma". J. Invest. Dermatol. 123 (6): 1127–34. doi:10.1111/j.0022-202X.2004.23467.x. PMID 15610524.
Wang J, He H, Yu L, Xia HH, Lin MC, Gu Q, Li M, Zou B, An X, Jiang B, Kung HF, Wong BC (2006). "HSF1 down-regulates XAF1 through transcriptional regulation". J. Biol. Chem. 281 (5): 2451–9. doi:10.1074/jbc.M505890200. PMID 16303760.
Yin W, Cheepala S, Clifford JL (2006). "Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1". Biochem. Biophys. Res. Commun. 339 (4): 1148–54. doi:10.1016/j.bbrc.2005.11.128. PMID 16343440.
Fang X, Liu Z, Fan Y, Zheng C, Nilson S, Egevad L, Ekman P, Xu D (2006). "Switch to full-length of XAF1 mRNA expression in prostate cancer cells by the DNA methylation inhibitor". Int. J. Cancer. 118 (10): 2485–9. doi:10.1002/ijc.21636. PMID 16353137. S2CID 43629966.
Gilli F, Marnetto F, Caldano M, Sala A, Malucchi S, Capobianco M, Bertolotto A (2006). "Biological markers of interferon-beta therapy: comparison among interferon-stimulated genes MxA, TRAIL and XAF-1". Mult. Scler. 12 (1): 47–57. doi:10.1191/135248506ms1245oa. PMID 16459719. S2CID 34530563.
Reu FJ, Bae SI, Cherkassky L, Leaman DW, Lindner D, Beaulieu N, MacLeod AR, Borden EC (2006). "Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation". J. Clin. Oncol. 24 (23): 3771–9. CiteSeerX 10.1.1.1025.9291. doi:10.1200/JCO.2005.03.4074. PMID 16801630.
Lee MG, Huh JS, Chung SK, Lee JH, Byun DS, Ryu BK, Kang MJ, Chae KS, Lee SJ, Lee CH, Kim JI, Chang SG, Chi SG (2006). "Promoter CpG hypermethylation and downregulation of XAF1 expression in human urogenital malignancies: implication for attenuated p53 response to apoptotic stresses". Oncogene. 25 (42): 5807–22. doi:10.1038/sj.onc.1209867. PMID 16909101.
Zou B, Chim CS, Zeng H, Leung SY, Yang Y, Tu SP, Lin MC, Wang J, He H, Jiang SH, Sun YW, Yu LF, Yuen ST, Kung HF, Wong BC (2006). "Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers". Gastroenterology. 131 (6): 1835–43. doi:10.1053/j.gastro.2006.09.050. PMID 17087954.
Micali OC, Cheung HH, Plenchette S, Hurley SL, Liston P, LaCasse EC, Korneluk RG (2007). "Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta". BMC Cancer. 7: 52. doi:10.1186/1471-2407-7-52. PMC 1845166. PMID 17376236.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Kempkensteffen C, Hinz S, Schrader M, Christoph F, Magheli A, Krause H, Schostak M, Miller K, Weikert S (2007). "Gene expression and promoter methylation of the XIAP-associated Factor 1 in renal cell carcinomas: correlations with pathology and outcome". Cancer Lett. 254 (2): 227–35. doi:10.1016/j.canlet.2007.03.006. PMID 17449173.
Shibata T, Mahotka C, Wethkamp N, Heikaus S, Gabbert HE, Ramp U (2007). "Disturbed expression of the apoptosis regulators XIAP, XAF1, and Smac/DIABLO in gastric adenocarcinomas". Diagn. Mol. Pathol. 16 (1): 1–8. doi:10.1097/01.pdm.0000213471.92925.51. PMID 17471152. S2CID 43822747.
Chung SK, Lee MG, Ryu BK, Lee JH, Han J, Byun DS, Chae KS, Lee KY, Jang JY, Kim HJ, Chi SG (2007). "Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses". Gastroenterology. 132 (7): 2459–77. doi:10.1053/j.gastro.2007.04.024. PMID 17570219.
Arora V, Cheung HH, Plenchette S, Micali OC, Liston P, Korneluk RG (2007). "Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex". J. Biol. Chem. 282 (36): 26202–9. doi:10.1074/jbc.M700776200. PMID 17613533.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132530 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040483 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12029096-5] Leaman DW, Chawla-Sarkar M, Vyas K, Reheman M, Tamai K, Toji S, Borden EC (Aug 2002). "Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis". J. Biol. Chem. 277 (32): 28504–11. doi:10.1074/jbc.M204851200. PMID 12029096.

[pmid11175744-6] Liston P, Fong WG, Kelly NL, Toji S, Miyazaki T, Conte D, Tamai K, Craig CG, McBurney MW, Korneluk RG (Feb 2001). "Identification of XAF1 as an antagonist of XIAP anti-Caspase activity". Nat. Cell Biol. 3 (2): 128–33. doi:10.1038/35055027. PMID 11175744. S2CID 19731886.

[entrez-7] "Entrez Gene: XAF1 XIAP associated factor-1".

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[3]

[4]

[5]

[6]

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Function

Interactions

References

Further reading