Captopril challenge test
| Captopril challenge test | |
|---|---|
 Captopril chemical structure. | |
| Purpose | measures the change in renin plasma-levels |
The captopril challenge test (CCT) is a non-invasive medical test that measures the change in renin plasma-levels in response to administration of captopril, an angiotensin converting enzyme inhibitor. It is used to assist in the diagnosis of renal artery stenosis. It is not generally considered a useful test for children,[1] and more suitable options are available for adult cases.
Procedure
[edit]Plasma concentration of renin is measured prior to and following the administration of captopril. The CCT is considered positive if the renin levels increase substantially or the baseline renin level is abnormally high.[2]
In adults
[edit]CCT in adults is known to have high sensitivity, but a low specificity.[3]
Subtraction angiography is considered a more suitable test for renal artery stenosis in adults.[4]
See also
[edit]- Captopril suppression test - used to diagnose primary aldosteronism
References
[edit]- ^ Gauthier, B.; Trachtman, H.; Frank, R.; Pillari, G. (1991). "Inadequacy of captopril challenge test for diagnosing renovascular hypertension in children and adolescents". Pediatric Nephrology (Berlin, Germany). 5 (1): 42–44. doi:10.1007/BF00852842. ISSN 0931-041X. PMID 2025535.
- ^ Muller, F. B.; Sealey, J. E.; Case, D. B.; Atlas, S. A.; Pickering, T. G.; Pecker, M. S.; Preibisz, J. J.; Laragh, J. H. (1986). "The captopril test for identifying renovascular disease in hypertensive patients". The American Journal of Medicine. 80 (4): 633–644. doi:10.1016/0002-9343(86)90819-3. ISSN 0002-9343. PMID 3515933.
- ^ Bales, A. (1999-05-01). "Hypertensive crisis. How to tell if it's an emergency or an urgency". Postgraduate Medicine. 105 (5): 119–126, 130. doi:10.3810/pgm.1999.05.1.735. ISSN 0032-5481. PMID 10335324.
- ^ Svetkey, L. P.; Himmelstein, S. I.; Dunnick, N. R.; Wilkinson, R. H.; Bollinger, R. R.; McCann, R. L.; Beytas, E. M.; Klotman, P. E. (1989). "Prospective analysis of strategies for diagnosing renovascular hypertension". Hypertension (Dallas, Tex.: 1979). 14 (3): 247–257. doi:10.1161/01.hyp.14.3.247. ISSN 0194-911X. PMID 2670763.