View source for Beta-phosphoglucomutase

{{Short description|Enzyme}}
{{infobox enzyme
| Name       = β-Phosphoglucomutase
| EC_number  = 5.4.2.6
| CAS_number = 68651-99-0
| GO_code    = 0008801
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], a '''β-phosphoglucomutase''' ({{EnzExplorer|5.4.2.6}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:β-D-glucose 1-phosphate <math>\rightleftharpoons</math> β-D-glucose 6-phosphate

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[β-D-glucose 1-phosphate]], and one [[product (chemistry)|product]], [[β-D-glucose 6-phosphate]].

This enzyme belongs to the family of [[isomerase]]s, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule.  The [[List of enzymes|systematic name]] of this enzyme class is '''beta-D-glucose 1,6-phosphomutase'''. This enzyme participates in [[starch and sucrose metabolism]].

==Structural studies==

20 [[tertiary structure|structures]] have been solved for this enzyme [[Protein Data Bank|PDB]]. Some of the accession codes are {{PDB link|1LVH}}, {{PDB link|1O03}}, {{PDB link|1O08}}, {{PDB link|1Z4N}}, {{PDB link|1Z4O}}, and {{PDB link|1ZOL}}. Most of these structures detail metal fluoride analogue complexes which are used to mimic different states along the reaction coordinate.

==References==
{{reflist|1}}
* {{cite journal | vauthors = Ben-Zvi R, Schramm M | date = 1961 | title = A phosphoglucomutase specific for beta-glucose 1-phosphate | journal = J. Biol. Chem.  | volume = 236 | issue = 8 | pages = 2186&ndash;2189 | doi = 10.1016/S0021-9258(18)64053-0 | doi-access = free }}
* {{cite book | veditors = Boyer PD | title = The Enzymes | edition = 3rd | volume = 6 | date = 1972 | pages = 407–477 }}

{{Mutases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 5.4.2]]
[[Category:Enzymes of known structure]]


{{isomerase-stub}}